Sökning: "citrate synthase"
Visar resultat 1 - 5 av 22 avhandlingar innehållade orden citrate synthase.
1. Mitochondrial function in human skeletal muscle: with special reference to exercise and training
Sammanfattning : The overall objective of this thesis was to study the adaptation of oxidative function in human skeletal muscle to acute exercise of different modes, intensities and durations, and to endurance training. The effects of endurance training on mitochondrial function were evaluated in cross-sectional and longitudinal studies by measurements of mitochondrial oxygen consumption in isolated mitochondria and permeabilised muscle fibres and measurements of mitochondrial ATP production rate in isolated mitochondria. LÄS MER
2. Engineering cytosolic acetyl-CoA metabolism in Saccharomyces cerevisiae
Sammanfattning : A Saccharomyces cerevisiae strain carrying deletions in all three pyruvate decarboxylase genes (also called Pdc negative yeast) represents a non-ethanol producing platform strain for biochemical production. However, it cannot grow on glucose as the sole carbon source due to the lack of cytosolic acetyl-CoA for lipid biosynthesis. LÄS MER
3. Molecular Simulation of Enzyme Catalysis and Inhibition
Sammanfattning : The reaction mechanisms for the hemoglobin degrading enzymes in the Plasmodium falciparum malaria parasite, plasmepsin II (Plm II) and histo-aspartic protease (HAP), have been analyzed by molecular simulations. The reaction free energy profiles, calculated by the empirical valence bond (EVB) method in combination with molecular dynamics (MD) and free energy perturbation (FEP) simulations are in good agreement with experimental data. LÄS MER
4. Enantioselective synthesis of citric acid analogues
Sammanfattning : The enantioselective synthesis of (1S,2S)- and (1R,2S)- fluorocitric acid is described. Toxic fluorocitric acid formed enzymaticly from fluoroacetic acid has the 1R,2R configuration. The enzyme citrate (si)-synthase catalyzes the formation of all four isomers of fluorocitric acid. LÄS MER
5. Rickettsia helvetica; Detection in arthropods and human tissues and its relation to clinical disease
Sammanfattning : A relation between R. helvetica and perimyocarditis was, in two young men who died of sudden cardiac death during exercise in 1997, suggested by a seminested PCR, for three different genes, sequencing of the amplified products, documentation of a seroresponse and histopathologic changes in accordance with rickettsioses. LÄS MER