Sökning: "ADP sensitivity"

Visar resultat 1 - 5 av 18 avhandlingar innehållade orden ADP sensitivity.

1. 1. Mitochondrial function in human skeletal muscle: with special reference to exercise and training

   Författare :Michail Tonkonogi; Högskolan Dalarna; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :aerobic metabolism; oxidative phosphorylation; mitochondria; oxygen utilisation; citrate synthase; ADP sensitivity; ATP; muscle fibres; hydrogen ions; lactate; free radicals; proton leak; uncoupling; exercise; aerobic metabolism; oxidative phosphorylation; mitochondria; oxygen utilisation; citrate synthase; ADP sensitivity; ATP; muscle fibres; hydrogen ions; lactate; free radicals; proton leak; uncoupling; exercise;

   Sammanfattning : The overall objective of this thesis was to study the adaptation of oxidative function in human skeletal muscle to acute exercise of different modes, intensities and durations, and to endurance training. The effects of endurance training on mitochondrial function were evaluated in cross-sectional and longitudinal studies by measurements of mitochondrial oxygen consumption in isolated mitochondria and permeabilised muscle fibres and measurements of mitochondrial ATP production rate in isolated mitochondria. LÄS MER

3. 2. Oxidant-induced cell death in lymphocytes: mechanisms of induction and resistance

   Författare :Fredrik Bergh Thorén; Göteborgs universitet; []
   Nyckelord :reactive oxygen species; cell death; apoptosis; poly ADP-ribose polymerase-1; apoptosis-inducing factor; natural killer cells; phagocytes; dendritic cells;

   Sammanfattning : Reactive oxygen species (oxidants, oxygen radicals) produced by the phagocytic NADPH oxidase have pivotal roles in immunity. Patients lacking a functional NADPH oxidase suffer from chronic granulomatous disease, which is characterized by recurring bacterial infections and thus manifesting the importance of reactive oxygen species in host defense against bacteria. LÄS MER

4. 3. The role of exercise and exercise-related factors in the control of mitochondrial oxidative function

   Författare :Brandon Walsh; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Skinned fibers; permeabilized fibers; skeletal muscle; exercise; mitochondria; ADP sensitivity; aerobic metabolism; training; eccentric; high intensity; creatine; phosphocreatine; inorganic phosphate; hydrogen ions;

   Sammanfattning : The effects of exercise and exercise-related factors on the control of mitochondrial oxidative function were investigated in human and rat skeletal muscle. Oxidative function was assessed through the measurement of oxygen consumption in chemically permeabilized (skinned) fibers. LÄS MER

5. 4. Variability and adaptation in the contractile system of smooth muscle

   Författare :Mia Löfgren; Institutionen för experimentell medicinsk vetenskap; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; essential light chain; desmin; shortening velocity; integrin; intermediate filament; hypertrophy; non-muscle myosin; smooth muscle; myosin; heavy chain; Physiology; Fysiologi;

   Sammanfattning : This thesis examines the cellular and molecular mechanisms involved in the large diversity of the contractile properties in smooth muscle. Six studies, I-VI, are included. I: a slow smooth muscle (aorta) has a different nucleotide and phosphate dependence compared to a fast type (taenia coli). LÄS MER

7. 5. Intracellular mechanisms of skeletal muscle fatigue : role of creatine kinase

   Författare :Anders Dahlstedt; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Skeletal muscle fatigue; creatine kinase; inorganic phosphate; adenosine diphosphate;

   Sammanfattning : During intense physical activity the maximal power output of skeletal muscles is reduced, a condition described as muscle fatigue. The cause of impaired muscle function seen in fatigue is multifactorial. LÄS MER