Sökning: "Berit Olofsson"

Visar resultat 1 - 5 av 14 avhandlingar innehållade orden Berit Olofsson.

  1. 1. A regio- and streodivergent synthesis of vic-amino alcohols

    Författare :Berit Olofsson; KTH; []
    Nyckelord :;

    Sammanfattning : .... LÄS MER

  2. 2. A Regio- and Stereodivergent Route to All Isomers of vic-Amino Alcohols

    Författare :Berit Olofsson; KTH; []
    Nyckelord :amino alcohols; vinylepoxides; vinylaziridines; oxazolines; oxazolidinones; ring-opening; regioselective; diastereoselective; sphingosine; configuration; NMR spectroscopy;

    Sammanfattning : The first part of this thesis describes a synthetic strategythat provides all eight possible isomers of a given vic-aminoalcohol starting from vinylepoxides. The value of a generalroute is evident, as several isomers are needed ininvestigations of structure-activity relationships forpharmacologically active derivatives, and for optimizing theperformance of chiral ligands containing the amino alcoholmoiety. LÄS MER

  3. 3. Diaryliodonium Salts : Development of Synthetic Methodologies and α-Arylation of Enolates

    Författare :Marcin Bielawski; Berit Olofsson; Antonio Togni; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Hypervalent Iodine Compounds; One-Pot Synthesis; Regiospecific Synthesis; Aromatic Substitution; Aryl Iodides; Arenes; Boronic Acids; Heteroaromatics; Arylations; Reaction Mechanisms; Density Functional Calculations; Large Scale Synthesis; Organic synthesis; Organisk syntes; organisk kemi; Organic Chemistry;

    Sammanfattning : This thesis describes novel reaction protocols for the synthesis of diaryliodonium salts and also provides an insight to the mechanism of α-arylation of carbonyl compounds with diaryliodonium salts.  The first chapter gives a general introduction to the field of hypervalent iodine chemistry, mainly focusing on recent developments and applications of diaryliodonium salts. LÄS MER

  4. 4. Efficient and High-Yielding Routes to Diaryliodonium Salts

    Författare :Marcin Bielawski; Berit Olofsson; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Hypervalent Iodine Compounds; One-Pot Synthesis; Regiospecific Synthesis; Aromatic Substitution; Aryl Iodides; Arenes; Boronic Acids; Organic chemistry; Organisk kemi;

    Sammanfattning : This thesis summarizes three novel and general reaction protocols for the synthesis of diaryliodonium salts. All protocols utilize mCPBA as oxidant and the acids used are either TfOH, to obtain triflate salts, or BF3•Et2O that gives the corresponding tetrafluoroborate salts in situ. LÄS MER

  5. 5. Synthetic and Mechanistic Studies with Iodine(III) Reagents

    Författare :Ester Maria Di Tommaso; Berit Olofsson; Marcos Suero; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; hypervalent iodine chemistry; organic synthesis; mechanistic studies; DFT; photocatalysis; Organic Chemistry; organisk kemi;

    Sammanfattning : This thesis describes the development of metal-free transformations and mechanistic studies on the reactivity of two classes of hypervalent iodine reagents: diaryliodonium salts and vinylbenziodoxolones (VBX). Recently, they have been recognized as valuable synthetic reagents with broad applicability in organic synthesis. LÄS MER