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Visar resultat 6 - 10 av 46 avhandlingar som matchar ovanstående sökkriterier.

  1. 6. Nitric oxide in brain contusion

    Författare :Caroline Gahm; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Apoptosis; Colchicine; Dexamethasone; eNOS; human; immunohistochemistry; iNOS; L-NAME; L-NIL; neuronal degeneration; Nimodipine; nitric oxide; NO; nNOS; rat; SPBN; Tirilazad Mesylate; traumatic brain injury;

    Sammanfattning : Trauma to the brain is a leading cause of death and disability. The primary injury initiates a cascade of biochemical reactions in the brain that causes further neuronal damage, a process referred to as secondary brain injury. LÄS MER

  3. 7. Cardioprotective mechanisms by inhibition of the HMG-CoA reductase pathway and stimulation of peroxisome proliferator-activated receptors in myocardial ischaemia-reperfusion

    Författare :Aliaksandr Bulhak; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Endothelial function; endothelin-1; geranylgeranyl pyrophosphate; HMG-CoA reductase; infarct size; ischaemiareperfusion injury; myeloperoxidase; myocardium; nitric oxide; nitric oxide synthase; peroxisome proliferator-activated receptor-alpha; -gamma; PPAR-alpha; -gamma-ligands; RhoA; statins.;

    Sammanfattning : Acute myocardial ischaemia causes metabolic changes and results in a rapid decrease in the energy available to the cell. This leads to cell injury that, depending on the length of the ischaemic time, is reversible or irreversible. LÄS MER

  4. 8. Role of GLP-1 receptor agonists in endothelial function

    Författare :Özlem Erdogdu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Type 2 diabetes;

    Sammanfattning : BACKGROUND: The leading cause of death for patients suffering from type 2 diabetes is macrovascular disease. Endothelial dysfunction is one of the earliest events identified in the pathogenesis of atherosclerosis. Hence, there is a need for finding glucose-lowering agents that cause direct positive effects on vasculature in diabetic patients. LÄS MER

  5. 9. Clinical and pathogenic aspects of otitis media

    Författare :Anna Granath; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : One study on clinical treatment strategies in otitis media and two studies elucidating immunological events in otitis media in vitro, were conducted and joined in this thesis. First, topical treatment with or without systemic antibiotics against tube associated otorrhea in children with recurrent acute otitis media was evaluated. LÄS MER

  7. 10. On certain genetic and metabolic risk factors for carotid stenosis and stroke

    Författare :Pär Wanby; Lars Brudin; Martin Carlsson; Milita Crisby; Linköpings universitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Carotid artery diseases; Carrier proteins; genetics; Cerebrovascular accident; Cerebrovascular disorders; Genetic predisposition to disease; Polymorphism; genetic; Medicine; Medicin; Medicin;

    Sammanfattning : The present study evaluated genetic and metabolic factors influencing the risk of acute cerebrovascular disease (CVD) and internal carotid artery stenosis (ICA stenosis) in a Swedish community. The threonine (T) containing protein of the FABP2 A54T gene polymorphism has a greater affinity for long chain fatty acids (FFAs) than the alanine (A) containing protein. LÄS MER