Sökning: "dynamic fragment-based approach"
Hittade 3 avhandlingar innehållade orden dynamic fragment-based approach.
1. Fragment-based drug discovery : Novel methods and strategies for identifying and evolving fragment leads
Sammanfattning : The need for new drugs became ever more apparent in the year 2020 when the world was faced with a viral pandemic. How drugs are discovered and their relevance to society became part of daily discussions in workplaces and homes throughout the world. Consequently, efficient strategies for preclinical drug discovery are clearly needed. LÄS MER
2. Dynamic Systems: Evaluation, Screening and Synthetic Application
Sammanfattning : The research work reported in the thesis deals with the development of dynamic covalent systems and their applications in evaluation and screening of protein-ligands and enzyme inhibitors, as well as in synthetic methodologies. The thesis is divided into four parts as described below. LÄS MER
3. Structural studies of drug targets and a drug metabolizing enzyme
Sammanfattning : The work presented in this thesis describes how structural information about a protein can be acquired, and how it can be used to answer scientific questions about proteins’ function, their dynamic behaviour and their interactions with other proteins or ligands.The catalytic function of the pyrimidine-degrading, drug metabolizing enzyme β-ureidopropionase (βUP) is dependent on the shift between oligomeric states. LÄS MER
