Sökning: "downregulation"

Visar resultat 11 - 15 av 348 avhandlingar innehållade ordet downregulation.

  1. 11. Role of inflammatory and mitochondria genes in adipose tissue and obesity

    Författare :Maria Kaaman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Obesity is rapidly increasing in prevalence around the world together with its complications such as dyslipidemia, cardiovascular disease (CVD) and insulin resistance, which eventually may lead to type 2 diabetes (T2DM). The excess of adipose tissue, the hallmark of obesity, led us to study the adipose tissue as a contributor to obesity and insulin resistance. LÄS MER

  3. 12. Functional Recovery after Experimental Stroke in Mice- Involvement of Enriched Environment, BDNF and Cell Genesis

    Författare :Josefine Nygren; Sektion IV; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuropsykologi; neurofysiologi; neurophysiology; Neurologi; Neurology; neuropsychology; functional recovery; focal ischemia; cell genesis; BDNF; enriched environment; mice;

    Sammanfattning : Stroke is caused by an obstruction of blood flow to a part of the brain, resulting in brain damage. Stroke is the third most common cause of death in the industrialized world, and the primary cause of adult-onset disability. LÄS MER

  4. 13. Protein tyrosine phosphatases : taking a 'redoxionist' look at PDGFR signaling

    Författare :Jeroen Frijhoff; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Protein Tyrosine Phosphatases (PTPs) are oxidized and inactivated by reactive oxygen species (ROS) upon stimulation of a wide range of cell surface receptors, including the platelet-derived growth factor (PDGF) receptor (PDGF R). Signaling via this receptor tyrosine kinase stimulates cell proliferation and migration, and it is associated with cancer and cardiovascular diseases. LÄS MER

  5. 14. Regulation of cytokine receptors and activity markers in eosinophilic inflammatory processes

    Författare :Cecilia Hellman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The eosinophil is an important effector cell in allergic inflammation and asthma and an increased number of eosinophils and eosinophil-derived cytotoxic proteins have been found in blood and airways of allergic patients. The life cycle of the eosinophil starts with differentiation of bone marrow progenitor cells. LÄS MER

  7. 15. Unraveling novel genes that are essential for acute myeloid leukemia and normal hematopoiesis

    Författare :Gözde Turköz; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Acute myeloid leukemia (AML) is the most common hematological malignancy among adults. This disease results from an abnormal expansion of myeloid progenitors that are blocked in differentiation. Malignant transformation arises from various genetic and epigenetic changes in hematopoietic stem cells (HSCs) that accumulate with age. LÄS MER