Sökning: "disease expression"
Visar resultat 1 - 5 av 2546 avhandlingar innehållade orden disease expression.
1. Chrohn's disease : aspects of epidemiology, clinical course, and faecal calprotectin
Sammanfattning : The overall aim of this thesis was to study epidemiological and clinical changes in the natural history of Crohn’s disease, its phenotype, the need for surgery and pharmacological therapy over time, as well as the role of faecal calprotectin as a biomarker of pathophysiology and disease course.An increased incidence and prevalence of Crohn’s disease was seen in the period 1963-2010. LÄS MER
2. Psoriatic arthritis: a complex disease : analyses on genetic and serological biomarkers and of comorbidity
Sammanfattning : Psoriatic Arthritis (PsA) is a heterogonous inflammatory arthritis associated with psoriasis. The disease leads to inflammation of peripheral joints, axial skeleton and/or enthesites, and can result in severe destruction of affected joints. LÄS MER
3. Expression profiling using manifold supports
Sammanfattning : Analyses of mRNA provides a condensed view of gene structure and quantitative analysis can reveal the induction of physiological or pathological gene expression programs. This thesis describes a new method for mRNA isolation, followed by sensitive real time detection via polymerase chain reaction (PCR), in order to quantitate transcripts of interest. LÄS MER
4. Immunopathology of Inflammatory Bowel Disease
Sammanfattning : Inflammatory bowel disease (IBD) is a chronic inflammatory condition affecting the gastrointestinal tract, with a remitting and relapsing course. There are two main forms of IBD: Crohn’s disease (CD) and ulcerative colitis (UC). LÄS MER
5. Genetic Studies of Psoriasis and Psoriatic Arthritis
Sammanfattning : Psoriasis and psoriatic arthritis are common chronic immune-mediated diseases of the skin and joints. Psoriasis affects approximately 2-3 % of the Caucasian population and about 30 % of all psoriasis patients develop psoriatic arthritis. LÄS MER