Avancerad sökning

Hittade 3 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Structure and function of trigeminal primary sensory neurons after peripheral nerve injury

    Författare :Ulf Bongenhielm; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :ankyrinG; chronic constriction injury; electron microscopy; electrophysiology; hyperexcitability; immunocytochemistry; inferior alveolar nerve; in situ hybridisation; nerve injury; neuroma; SNS PN3; sodium channel; trigeminal ganglion;

    Sammanfattning : Iatrogenic injuries to branches of the trigeminal nerve are common during surgical procedures in the jaws and teeth, and as the repercussion of facial fractures or certain pathologies. A portion of these patients are left with disturbed sensory functions, and some with unpleasant abnormal sensations, including pain. LÄS MER

  3. 2. Tetrodotoxin-resistant sodium channels in neuropathic pain

    Författare :Jenny Fjell Hjelmström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :spinal sensory neurons; nociceptor; IB4; tetrodotoxin; sodium channels; SNS PN3; NaN SNS2; gene regulation; NGF; GDNF; in situ hybridization; immunofluorescence; sodium currents; neuropathic pain models; Taiep;

    Sammanfattning : Injury to the peripheral nervous system can cause neuropathic pain. Abnormal sodium channel activity has been implicated as a source of ectopic firing and changes in nociceptive threshold following nerve injury. LÄS MER

  4. 3. Neuropeptides, sensory neurons and pain modulation

    Författare :Pablo R Brumovsky; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : In the present thesis work we have analyzed the expression, regulation and function of two neuropeptides: galanin and neuropeptide tyrosine (NPY). Their associated receptors, galanin receptor-1 and -2 (GaIR1, -R2) and NPY Y1- and Y2R, were also studied. LÄS MER