Sökning: "cell-cell interactions"

Visar resultat 16 - 20 av 76 avhandlingar innehållade orden cell-cell interactions.

1. 16. It Takes Two to Tango : Bacterial heterogeneity and host cell features govern Salmonella infection

   Författare :Viktor Ek; Mikael E. Sellin; Francisco García del Portillo; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Salmonella; swimming; swim pattern; targetting; virulence; invasion; host-pathogen interactions; epithelium; epithelial cells; macrophages; monocytes; monolayer; flagella; genome; genetic; barcoding; discreet-invasion; shape; morphology; antibiotics; persistence; Mikrobiologi; Microbiology;

   Sammanfattning : Salmonella enterica serovar Typhimurium (S.Tm) causes enterocolitis with significant worldwide morbidity and mortality. The general aim of this thesis is to investigate variation in host cell invasion mechanisms used by S.Tm across different host cell contexts, as well as the influence of bacterial cell-cell heterogeneity on invasion-relevant S. LÄS MER

3. 17. Development of Microchip-based Assays to Study Immune Cell Interactions at the Single Cell Level

   Författare :Karolin Guldevall; Björn Önfelt; Hjalmar Brismar; Antonio Barragan; KTH; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Bioengineering; Bioteknik;

   Sammanfattning : Immune cell populations are constantly divided into smaller and smaller subsets defined by newly emerging cellular markers. However, there is a growing awareness of the functional heterogeneities in between cells even within small populations, in addition to the heterogeneity over time. LÄS MER

4. 18. Investigating a cell replacement therapy in the inner ear

   Författare :Zhengqing Hu; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Adult neural stem cell; Cell therapy; Differentiation; Dorsal root ganglion; Embryonic stem cell; Gene transfer; Hearing loss; Nerve growth factor; Neurogenin; Organ of Corti; Spiral ganglion; Transplantation;

   Sammanfattning : The mammalian auditory system is sensitive to genetic disorders, aging and injuries caused by overstimulation, ototoxic drugs and viral infections. Since the sensory epithelium (the organ of Corti) and the spiral ganglion neurons (SGNs) in adult mammalian do not regenerate spontaneously when they are damaged, a cell substitution strategy was proposed to compensate the function of the degenerated SGNs. LÄS MER

5. 19. Creating cell microenvironments in vitro

   Författare :Patric Wallin; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cell migration; lipid bilayers; cell differentiation; liquid handling; surface functionalization; Microfluidics; chemotractant gradients; mammalian cell culture; cell microenvironments; in vitro screening assay;

   Sammanfattning : Stem cells have a great potential to bring about advancements in fields like developmental biology, drug discovery, cancer biology and tissue engineering. In order to be able to use stem cells to their full potential, it is important to have control over their behavior. LÄS MER

7. 20. Dysregulated Notch signaling in breast cancer and liver disease

   Författare :Indira Chivukula; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The evolutionarily conserved Notch signaling pathway regulates crucial aspects of development and tissue homeostasis. This thesis contributes research towards understanding a role of non-canonical Notch signaling in the tumor-stroma interaction of breast cancer, provides a bioinformatics-based technology to study these interactions, and proposes a novel mouse model of the liver disease in Alagille syndrome. LÄS MER