Sökning: "targetting"

Hittade 5 avhandlingar innehållade ordet targetting.

  1. 1. It Takes Two to Tango : Bacterial heterogeneity and host cell features govern Salmonella infection

    Författare :Viktor Ek; Mikael E. Sellin; Francisco García del Portillo; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Salmonella; swimming; swim pattern; targetting; virulence; invasion; host-pathogen interactions; epithelium; epithelial cells; macrophages; monocytes; monolayer; flagella; genome; genetic; barcoding; discreet-invasion; shape; morphology; antibiotics; persistence; Mikrobiologi; Microbiology;

    Sammanfattning : Salmonella enterica serovar Typhimurium (S.Tm) causes enterocolitis with significant worldwide morbidity and mortality. The general aim of this thesis is to investigate variation in host cell invasion mechanisms used by S.Tm across different host cell contexts, as well as the influence of bacterial cell-cell heterogeneity on invasion-relevant S. LÄS MER

  3. 2. Lung-resident, M2e-specific CD4 T cells critically protect during influenza infection

    Författare :Ajibola Omokanye; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; influenza; vaccine; universal; heterosubtypic; M2e; CD4; Th17; ThCTL; tissue-resident; cytotoxic; single-cell RNA-seq;

    Sammanfattning : Memory CD4+ T cells are a critical component of the adaptive immune response to fight infection. However, current vaccines against influenza only focus on the other arm of adaptive immunity—triggering B cells to produce antibodies. LÄS MER

  4. 3. Avidity-guided radionuclide therapy for thyroid cancer

    Författare :Joachim Nilsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The treatment of differentiated thyroid cancer has three main modalities: surgery, hormone suppression and radioiodine therapy. Effective radioiodine therapy requires cancer cells to be iodine avid, i.e. exhibit relatively functional iodine transport and retention. LÄS MER

  5. 4. Utilizing Heterogeneity in Manycore Architectures for Streaming Applications

    Författare :Süleyman Savas; Tomas Nordström; Zain Ul-Abdin; Håkan Grahn; Högskolan i Halmstad; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Manycores; parallel architectures; parallelism; streaming applications; dataflow; manycore design; heterogeneous manycores;

    Sammanfattning : In the last decade, we have seen a transition from single-core to manycore in computer architectures due to performance requirements and limitations in power consumption and heat dissipation. The first manycores had homogeneous architectures consisting of a few identical cores. LÄS MER

  7. 5. Regulation of survival and proliferation of human intestinal epithelial cells by leukotriene D4

    Författare :Sailaja Paruchuri; Malmö Experimentell patologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Rac; General pathology; pathological anatomy; Patologi allmän ; patologisk anatomi; PI3K; CREB; p90RSK; Erk-1 2; PKC; inflammation; migration apoptosis; proliferation; LTD4; cell survival;

    Sammanfattning : The pro-inflammatory mediator, Leukotriene D4 (LTD4) is a product of arachidonic acid cascade and has been implicated in asthma and inflammatory bowel diseases. Prolonged inflammatory conditions like ulcerative colitis increases the risk for the development of cancer and the factors that induce the chronic immune response remain uncertain. LÄS MER