Sökning: "Neurogenin"

Hittade 5 avhandlingar innehållade ordet Neurogenin.

1. 1. Investigating a cell replacement therapy in the inner ear

   Författare :Zhengqing Hu; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Adult neural stem cell; Cell therapy; Differentiation; Dorsal root ganglion; Embryonic stem cell; Gene transfer; Hearing loss; Nerve growth factor; Neurogenin; Organ of Corti; Spiral ganglion; Transplantation;

   Sammanfattning : The mammalian auditory system is sensitive to genetic disorders, aging and injuries caused by overstimulation, ototoxic drugs and viral infections. Since the sensory epithelium (the organ of Corti) and the spiral ganglion neurons (SGNs) in adult mammalian do not regenerate spontaneously when they are damaged, a cell substitution strategy was proposed to compensate the function of the degenerated SGNs. LÄS MER

3. 2. Stem cells : proliferation, differentiation, migration

   Författare :Anna Falk; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Embryonic stem cell; adult neural stem cells; proliferation; differentiation; migration;

   Sammanfattning : A stem cell is demanding and requires precise conditions to carry out its unique tasks. This includes proliferation as an undifferentiated stem cell, differentiation to more mature cell types, migration through tissue to its final destination, and functional integration into the cellular network. LÄS MER

4. 3. Neurogenesis, neural stem cells and nitric oxide in neuroinflammation

   Författare :Alexandre I Danilov; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Neurogenesis; neuronal stem cells; nitric oxide; Multiple Sclerosis; EAE; brain trauma;

   Sammanfattning : We investigated whether nitric oxide (NO) is produced in MS patients, determining the concentrations of its oxidation products (NOx) in CSF. The total levels of NOx in CSF were significantly increased in all MS groups as compared to healthy controls and tension headache patients. LÄS MER

5. 4. Adult neural stem cells in neuroinflammation

   Författare :Ruxandra Covacu; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Neural stem cells; inflammation; EAE; NO; neurogenesis; HMGB1; TLR; TNFalpha;

   Sammanfattning : Adult neural stem cells (NSC) can be isolated from the subventricular zone (SVZ) of the lateral ventricles, the subgranular zone (SGZ) of the hippocampus and the central canal of the spinal cord. These cells are thought to have regenerative potential and pose important therapeutic possibilities in neuroinflammatory conditions such as Multiple Sclerosis (MS). LÄS MER

7. 5. Directed differentiation of adult neural stem cells for cell therapy in the nervous system

   Författare :Niklas Holmström; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The emergence of neural stem cell research has raised hopes for cell therapy of neurological disorders. Insight into the normal mechanisms of neural stem cell fate specification and differentiation is a prerequisite for the development of safe and efficient clinical applications. LÄS MER