Sökning: "botulinum neurotoxins"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden botulinum neurotoxins.

  1. 1. Botulinum neurotoxins

    Författare :Sara Persson Košenina; Pål Stenmark; Rongsheng Jin; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; botulinum neurotoxins; biokemi; Biochemistry;

    Sammanfattning : Botulinum neurotoxins (BoNTs) are the most potent toxins known to man, with less than 1 μg of pure toxin being enough to kill an adult man. Despite the high toxicity, BoNTs are widely used in cosmetics and in medicine for the treatment of an increasing number of medical conditions. LÄS MER

  3. 2. Structural Insights into Botulinum Neurotoxins and the ALFA-tag System : Structural and Functional Studies of Proteins Related to the Botulinum Neurotoxins and Design of a Novel Epitope Tag

    Författare :Markel Martínez-Carranza; Pål Stenmark; Thomas Binz; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; botulinum neurotoxin; Biochemistry; biokemi;

    Sammanfattning : This thesis is divided into two sections; the first part describes our work in the field of botulinum neurotoxins (presented in papers I, II, III, and manuscript IV) and the second part summarizes our work involving the design of a new biochemical tool (presented in paper V).Botulinum neurotoxins (BoNTs) produced by the anaerobic bacterium Clostridium botulinum are the most poisonous substances known to date. LÄS MER

  4. 3. Structural and functional studies of a novel Botulinum neurotoxin and of MTH1

    Författare :Linda Henriksson; Pål Stenmark; Maria Selmer; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Botulinum neurotoxin; botulism; cancer; gene cluster; molecular structures; MTH1; NTNH; oxidised nucleotides; progenitor complex; protein expression; protein purification; X-ray crystallography; Biochemistry; biokemi;

    Sammanfattning : X-ray crystallography visualizes the three dimensional molecular structures of proteins at atomic resolution. Seeing the molecular structure of a biomedically interesting protein enables a higher understanding of its function. LÄS MER

  5. 4. Structural and functional studies of proteins of medical relevance : Protein-ligand complexes in cancer and novel structural folds in bacteria

    Författare :Robert Gustafsson; Pål Stenmark; Pavlína Řezáčová; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; X-ray crystallography; Cancer; MTH1; oxidised nucleotides; MTHFD2; nucleotide metabolism; one-carbon metabolism; Botulism; Botulinum neurotoxin; OrfX; OrfX gene cluster; Biochemistry; biokemi;

    Sammanfattning : X-ray crystallography is a tool for determining the structures of proteins and protein-ligand complexes. In this thesis the method has been employed to study several proteins of medical relevance.Cancer is a terrible disease, severely impacting those affected, as well as their family and friends. LÄS MER

  7. 5. Genomic organization and diversity of Clostridium botulinum group III : the bug behind animal botulism

    Författare :Hanna Skarin; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES;

    Sammanfattning : Botulism is caused by botulinum neurotoxins (BoNTs) produced by the spore forming strictly anaerobic bacterium Clostridium botulinum. Seven different types of BoNTs (type A-F) have so far been established on the basis of neutralization with different antibodies. LÄS MER