Sökning: "Maria Selmer"
Visar resultat 1 - 5 av 10 avhandlingar innehållade orden Maria Selmer.
1. Protein-RNA interplay in translation. Structural studies of RRF, SelB and L1
Sammanfattning : Translation is a central biological process, that is catalysed by a machinery consisting of RNA and protein. In this thesis three different protein components of the bacterial protein synthesis system have been structurally studied. LÄS MER
2. Structural and Biochemical Studies of Antibiotic Resistance and Ribosomal Frameshifting
Sammanfattning : Protein synthesis, translation, performed by the ribosome, is a fundamental process of life and one of the main targets of antibacterial drugs. This thesis provides structural and biochemical understanding of three aspects of bacterial translation.Elongation factor G (EF-G) is the target for the antibiotic fusidic acid (FA). LÄS MER
3. Post-synaptic Density Disc Large Zo-1 (PDZ) Domains : From Folding and Binding to Drug Targeting
Sammanfattning : Understanding how proteins fold and bind is interesting since these processes are central to most biological activity. Protein folding and protein-protein interaction are by themselves very complex but using a good and robust system to study them could ease some of the hurdles. LÄS MER
4. Life will find a way : Structural and evolutionary insights into FusB and HisA
Sammanfattning : How do microbes adapt to challenges from the environment? In this thesis, two distinct cases were examined through structural and biochemical methods. In the first, we followed a real-time protein evolution of HisA to a novel function. The second case was fusidic acid (FA) resistance mediated by the protein FusB in Staphylococcus aureus. LÄS MER
5. Structural and functional studies of a novel Botulinum neurotoxin and of MTH1
Sammanfattning : X-ray crystallography visualizes the three dimensional molecular structures of proteins at atomic resolution. Seeing the molecular structure of a biomedically interesting protein enables a higher understanding of its function. LÄS MER