Sökning: "bacterial receptor"

Visar resultat 11 - 15 av 193 avhandlingar innehållade orden bacterial receptor.

  1. 11. Phagocytic-receptor signaling in human neutrophils

    Författare :Ragnhild Löfgren; Matthias P. Wymann; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : The neutrophil granulocyte is one of the most mobile cells in the body and through a number of functions represents the first line of defense against invading pathogens. Adhesion and chemotactic receptors on the cell surface work together through modulation of the cytoskeleton, thereby enabling cell movement. LÄS MER

  3. 12. The Interleukin-1 family of proteins in the brain and adrenal gland : regulation in response to bacterial LPS

    Författare :Susanne Tingsborg; Fred J.H. Tilders; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurochemistry; Neurokemi; Neurochemistry and Neurotoxicology; neurokemi och neurotoxikologi;

    Sammanfattning : Interleukin-1 (IL-1) is mediating diverse physiological conditions as inflammatory response, fever and sickness behaviour but also, via activation of the hypothalamus-pituitary-adrenal (HPA)-axis, the release of the anti-inflammatory adrenocorticoids. The neuroendocrine system as well as the central nervous system (CNS) is involved in the regulation of these conditions in the body. LÄS MER

  4. 13. Role of macrophage receptor MARCO in host defense

    Författare :Marko Sankala; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MARCO; innate immunity; scavenger receptor.;

    Sammanfattning : Innate immunity, the first line of defense against infectious microorganisms, appeared early in evolution. Innate immunity relies on specialized cells such as macrophages that are the first to encounter pathogens during infection. LÄS MER

  5. 14. CD64 (FcγRI) Expression on Neutrophil Granulocytes : A Diagnostic Marker of Acute Bacterial Infections

    Författare :Gustav Fjaertoft; Tony Foucard; Per Venge; Stelllan Håkansson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pediatrics; CD64; FcγRI; Neutrophil; Infection; Newborn; Neonate; Pediatrik; Paediatric medicine; Pediatrisk medicin;

    Sammanfattning : Background. Newborn infants, especially preterm infants, have an increased susceptibility to serious and overwhelming bacterial as well as fungal infections. Symptoms of septicaemia in especially the very preterm neonates are vague and unspecific. LÄS MER

  7. 15. Engineering Antibody Specificity Using Combinatorial Antibody Libraries

    Författare :Jenny Boström; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; antibody Antigen Interactions; Dual Specific Antibodies; Herceptin; Human Epidermal Growth Factor Receptor 2; Thermodynamic Analysis; therapeutic Antibody Engineering; Synthetic Phagedisplayed Antibody Libraries; Vascular Endothelial Growth Factor; Bacterial Display; trastuzumab;

    Sammanfattning : The research presented in this thesis investigates antibody specificity, antibody-antigen and protein-protein interactions using combinatorial antibody libraries, phage-display and bacterial display technology. One goal was to develop a method to generate antibodies that bind two protein antigens with high affinity using a single-antigen binding site, and to investigate the molecular and thermodynamic requirements for antibody multispecificity. LÄS MER