Sökning: "asymmetric hydrogenation"

Visar resultat 41 - 45 av 60 avhandlingar innehållade orden asymmetric hydrogenation.

1. 41. Synthesis of aromatic bis- and tris(amino acids) and chiral dendrimers

   Författare :Andreas Ritzén; Centrum för analys och syntes; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organisk kemi; Organic chemistry; HWE reaction; asymmetric hydrogenation; Heck reaction; Amino acids; chiral dendrimers;

   Sammanfattning : A number of protected aromatic bis- and tris(amino acids) have been synthesised by catalytic asymmetric hydrogenation of the corresponding didehydroamino acid derivatives. The didehydroamino acid derivatives were prepared either by a Heck coupling of a 2-amidoacrylate with an aryl dihalide, or by Horner-Wadsworth-Emmons olefination of aromatic aldehydes with phosphonylglycine reagents. LÄS MER

3. 42. An Organic Chemistry Odyssey : Imaging Mass Spectrometry in Neurotherapeutics, Asymmetric Methodology Development and Natural Product Synthesis

   Författare :Marvin Villacrez; Kemisk biologi med inriktning mot läkemedelsutveckling; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Masspektrometri; totalsyntes; avbildande massspektrometri; MALDI avbildande massspektrometri; asymmetrisk syntes; farmakokinetik; dynamisk kinetisk resolution; Aasymetrisk överföringshydrogenering; klozapin; Läkemedelsmetabolism; läkemedelsdistribution; aminoalkoholer; Aspidophylline A; mass spectromery; Imaging mass spectrometry; Total synthesis; Dynamic kinetic resolution; asymmetric transfer hydrogenation; Aspidophylline A; Drug distribution; Drug metabolism; Drug Metabolism and Mass Spectrometry Imaging; MALDI mass spectrometry imaging; clozapine; amino alcohols; pharmacokinetics;

   Sammanfattning : The development of imaging technologies and brain models is crucial for advancements in neurotherapeutic drug discovery and development. They assume a critical role in evaluating essential parameters such as drug blood-brain barrier (BBB) permeation, distribution, and metabolism, all of which are vital for the development of safe and effective medications. LÄS MER

4. 43. Asymmetric transfer hydrogenation of aromatic ketones and azirines with NH-ligands

   Författare :Peter Roth; Krister Zetterberg; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; Organisk kemi; Organic chemistry; Organisk kemi; organisk kemi; Organic Chemistry;

   Sammanfattning : The Ru(arene)[(1S, 3R, 4R)-3-(Hydroxymethyl)-2-azabicyclo[2.2.1]heptane catalyst was optimized as ligand in the asymmetric transfer hydrogenation of ketones and resulted in increased activity and enantioselectivity of the catalyst. LÄS MER

5. 44. Rhodium-catalyzed asymmetric transfer hydrogenation of ketones. Ligand development and mechanistic investigation

   Författare :Katrin Ahlford; Stockholms universitet; []
   Nyckelord :;

   Sammanfattning : .... LÄS MER

7. 45. N-Heterocyclic Carbene-Phosphine Iridium Catalyzed Alkylation Reactions and Asymmetric Hydrogenation of Ketones

   Författare :Sutthichat Kerdphon; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; C-C coupling reactions; hydrogen transfer; iridium; ketones; methylation;

   Sammanfattning : This thesis is focused on hydrogen transfer reactions using N-heterocyclic carbenephosphine iridium catalysts and is divided in two parts. The first part describes the use of achiral N-heterocyclic carbene-phosphine iridium complexes catalyzing the methylation of ketones and alkylation of amides using alcohols as the electrophile. LÄS MER