Sökning: "Heck reaction"

Visar resultat 1 - 5 av 42 avhandlingar innehållade orden Heck reaction.

  1. 1. Palladium(II)-Catalyzed Heck Reactions : Domino Reactions, Decarboxylations, Mechanistic Studies & Continuous Flow Applications

    Författare :Ashkan Fardost; Mats Larhed; Patrick Guiry; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; palladium II ; dft; reaction mechanisms; esi-ms; heck; decarboxylation; microwave; continuous flow;

    Sammanfattning : This thesis describes research efforts dedicated to the development of palladium(II)-catalyzed oxidative Heck and Heck/Suzuki domino reactions, and the applications of a new microwave heating technology, purpose-built for continuous flow in organic synthesis.Paper I describes the development of a ligand-modulated approach for attaching aryl groups to a chelating vinyl ether. LÄS MER

  2. 2. Targeted proteomics methods for protein quantification of human cells, tissues and blood

    Författare :Fredrik Edfors; Mathias Uhlén; Albert Heck; KTH; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; proteomics; mass spectrometry; protein quantification; stable isotope standard; parallel reaction monitoring; immuno-enrichment; Bioteknologi; Biotechnology;

    Sammanfattning : The common concept in this thesis was to adapt and develop quantitative mass spectrometric assays focusing on reagents originating from the Human Protein Atlas project to quantify proteins in human cell lines, tissues and blood. The work is based around stable isotope labeled protein fragment standards that each represent a small part of a human protein-coding gene. LÄS MER

  3. 3. Heck Reactions with Aryl Chlorides : Studies of Regio- and Stereoselectivity

    Författare :Gopal K. Datta; Mats Larhed; Anders Hallberg; Martin Oestreich; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Heck reaction; aryl chloride; vinyl ether; regioselective; stereoselective; palladium; chelation control; microwave; Pharmaceutical chemistry; Farmaceutisk kemi;

    Sammanfattning : Homogeneous palladium-catalyzed Heck vinylation of aryl chlorides was investigated under air using Herrmann’s palladacycle and the P(t-Bu)3-liberating salt [(t-Bu)3PH]BF4. Based on the results, controlled microwave heating was utilized to accelerate model Heck reactions with aryl chlorides down to 30 min employing an electron-poor olefin and a mixture of an ionic liquid and 1,4-dioxane as solvent. LÄS MER

  4. 4. Synthesis and Evaluation of N,P-Chelating Ligands in Asymmetric Transition-Metal-Catalyzed Reactions : Ir-Catalyzed Asymmetric Hydrogenation and Pd-Catalyzed Asymmetric Intermolecular Heck Reaction

    Författare :Päivi Tolstoy; Pher G. Andersson; Göran Hilmersson; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; Asymmetric hydrogenation; Heck reaction; N; P ligand; Iridium; Palladium; Asymmetric catalysis; Alkenes; Fluorine; Diarylmethine stereocenters; Chemistry; Kemi; organisk kemi; Organic Chemistry;

    Sammanfattning : This thesis describes synthesis of new chiral N,P ligands and their evaluation in two types of asymmetric transition-metal catalyzed reactions. The first part of the thesis describes studies in iridium-catalyzed asymmetric hydrogenation. LÄS MER

  5. 5. Novel Metal-Mediated Organic Transformations : Focusing on Microwave Acceleration and the Oxidative Heck Reaction

    Författare :Per-Anders Enquist; Mats Larhed; Anders Hallberg; Troels Skrydstrup; Uppsala universitet; []
    Nyckelord :Organic chemistry; palladium II ; oxidative Heck reaction; high-throughput-chemistry; microwave acceleration; dicobalt octacarbonyl; in situ carbonylation; urea; diaryl ketones; ESI-MS; Organisk kemi;

    Sammanfattning : Transition metals have played an important role in synthetic organic chemistry for more than a century, and offer catalytic transformations that would have been impossible with classical chemistry. One of the most useful and versatile of the transition metals is palladium, which over the years has catalyzed many important carbon-carbon forming reactions. LÄS MER