Sökning: "allodynia"

Visar resultat 11 - 15 av 34 avhandlingar innehållade ordet allodynia.

1. 11. Treatment of pain behavior after spinal cord injury in rats with special emphasis on the role of adenosine receptors

   Författare :Margareta von Heijne; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :adenosine; adenosine receptors; allodynia; baclofen; central pain; clonidine; intrathecal; morphine; neuropathic pain; opioid; rat; R-phenylisopropyladenosine; spinal cord injury; tolerance;

   Sammanfattning : Central pain is a form of neuropathic pain occurring after injury or dysfunction in the central nervous system, including the spinal cord. Allodynia (pain to innocuous stimuli) to mechanical and cold stimulation is a common feature of central pain and it is often resistant to treatment. LÄS MER

3. 12. Central pain after spinal cord injury : experimental studies with special emphasis on pharmacological treatment

   Författare :Wei Yu; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :allodynia; central pain; ischemia; spinal cord injury; intrathecal; opioid; opioid receptors; selective opioid agonists; selective opioid antagonists; tolerance; dependence; clonidine; bovine chromaffin cells; encapsulation; resiniferatoxin;

   Sammanfattning : Injuries and dysfunctions of the central nervous system can cause central pain which, according to clinical experience, is often refractory to conventional treatments. The present thesis consists of experimental studies on the mechanisms and treatments of central pain using a well-established animal model of central pain after spinal cord injury. LÄS MER

4. 13. Cell therapy for spinal cord injury, studies of motor and sensory systems

   Författare :Christoph Hofstetter; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Nervous system; spinal cord injury; pseudorabies virus; axonal tracing; functional MRI; stereology; Rho-kinases; transplantation; stem cells; neurogenin2; allodynia;

   Sammanfattning : Spinal cord injury represents a significant medical concern, affecting thousands of individuals each year. The majority of victims are young males harmed by traffic accidents, violence, and falls. Severe spinal cord injury interupts nerve fiber pathways connecting the brain and the rest of the body. LÄS MER

5. 14. On the function endogenous pain controlling systems in healthy subjects and patients with peripheral or central neuropathic pain

   Författare :Birgitta Tuveson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Painful peripheral neuropathy; Central post-stroke pain; Dynamic mechanical allodynia; Endogenous pain modulation; Heterotopic noxious conditioning stimulation; Quantitative sensory testing; Ondansetron;

   Sammanfattning : Introduction and aim: Activity in the nociceptive system is modulated by descending inhibitory and facilitatory supraspinal endogenous control. Altered balance between inhibition and facilitation has been suggested to at least partly explain the maintenance of some persistent pain conditions. LÄS MER

7. 15. Adult human neural stem cells : properties in vitro and as xenografts in the spinal cord

   Författare :Ulf Westerlund; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Action potential; adult; allodynia; auto-transplantation; endoscope; glutamate; hippocampus; human; neural stem cells; p75; patch clamp; progenitor; spinal cord injury; subventricular zone; synapse; transplantation;

   Sammanfattning : Though the presence of stem cells in the adult human brain has been presented earlier, much has yet to be discovered about these cells. However, the mere potential of these cells has had a significant impact of how we today evaluate the regenerative capacity of the central nervous system and, importantly, on the possible means for science to provide insights in neural repair. LÄS MER