Sökning: "allodynia"

Visar resultat 16 - 20 av 34 avhandlingar innehållade ordet allodynia.

1. 16. Somatosensory dysfunctin in fibromyaligia : implications for pathophysiological mechanisms

   Författare :Eva Kosek; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :allodynia; diffuse noxious inhibitory controls DNIC ; fibromyalgia; hyperesthesia; isometric contraction; pain modulation; pain inhibition; pressure algometry; quantitative sensory testing; sensitivity; sensitization; tourniquet test; v;

   Sammanfattning : Fibromyalgia is a chronic pain syndrome characterized by generalized pain, tenderness, disturbed sleep and pronounced fatigue. The pathophysiology is unknown but peripheral mechanisms (i.e., muscle ischemia) as well as central mechanisms (dysfunction in endogenous pain modulation) have been implicated. LÄS MER

3. 17. The Impact of the Neuropeptide Substance P (SP) Fragment SP1-7 on Chronic Neuropathic Pain

   Författare :Anna Jonsson; Fred Nyberg; Mathias Hallberg; James Zadina; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuropathic pain; substance P SP ; SP1-7; bioactive fragments; spared nerve injury; spinal cord injury; streptozotocin-induced diabetes; allodynia; hyperalgesia; peptidomimetics; cerebrospinal fluid; spinal cord stimulation; radioimmunoassay; Pharmaceutical Science; Farmaceutisk vetenskap;

   Sammanfattning : There is an unmet medical need for the efficient treatment of neuropathic pain, a condition that affects approximately 10% of the population worldwide. Current therapies need to be improved due to the associated side effects and lack of response in many patients. LÄS MER

4. 18. Pain influences somatosensory perception : an experimental and clinical study

   Författare :Ann-Sofie Leffler; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Muscle pain; referred pain; hypoaesthesia; allodynia; musculoskeletal; pain; sensory abnormality; quantitative sensory testing; trapezius myalgia; somatosensory perception; perception thresholds; diffuse noxious inhibitory controls DNIC ; central hyperexcitability; tourniquet test; cold-pressor test.;

   Sammanfattning : The underlying mechanisms maintaining long-term pain localised to musculoskeletal structures and joints are not infrequently unknown. In routine clinical work with such patients insufficient attention has been paid to phenomena indicating altered excitability of the central nervous system (CNS). LÄS MER

5. 19. Spinal cord stimulation in neuropathy : experimental studies of biochemistry and behaviour

   Författare :Jian-Guo Cui; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Neuropathic pain; mononeuropathy; GABA; glutamate; aspartate; galanin; neuropeptide Y; adenosine; spinal cord stimulation;

   Sammanfattning : Neuropathic pain, presenting with cutaneous hypersensitivity, i.e. allodynia, dysesthesia and hyperalgesia, is often difficult to manage with pharmacotherapy, but may be effectively alleviated by electric spinal cord stimulation (SCS). However, the mode of action of SCS is still poorly understood. LÄS MER

7. 20. Sex differences in acute and chronic experimental pain models

   Författare :Lili Li; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :estrogen;

   Sammanfattning : Sex differences in response to noxious stimuli and in the development of chronic pain have been increasingly recognized and studied in humans and laboratory animals. In the clinic, extensive evidence indicates that there are a large number of chronic pain conditions that have higher prevalence in women than in men and some of these conditions, such as migraine and temporomandibular pain disorder, are also affected by the menstrual cycle. LÄS MER