Sökning: "UBL"

Visar resultat 1 - 5 av 7 avhandlingar innehållade ordet UBL.

  1. 1. Function and targets of the Urm1/Uba4 conjugation machinery in Drosophila melanogaster

    Författare :Behzad Khoshnood; Caroline Grabbe; Tor Erik Rusten; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Drosophila; Urm1; Uba4; MOCS3; Tax; HTLV; Posttranslational modification; ubiquitin-like modifiers; UBL; PTM; JNK; neuromuscular junctions; signaling; molekylärbiologi; Molecular Biology;

    Sammanfattning : Posttranslational modification (PTM) of proteins is essential to maintain homeostasis and viability in all eukaryotic cells. Hence, besides the sequence and 3D folding of a polypeptide, modification by multiple types of PTMs, ranging from small molecular groups to entire protein modules, adds another layer of complexity to protein function and regulation. LÄS MER

  3. 2. Structural, Dynamic and Functional Studies of USP14 : A Proteasome-Associated Deubiquitinating Enzyme Regulating Protein Degradation

    Författare :Johannes Salomonsson; Maria Sunnerhagen; Alexandra Ahlner; Eleonore von Castelmur; Pau Bernadó; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Ubiquitin-Specific Protease 14 (USP14) is a proteasome-associated deubiquitinating enzyme (DUB) involved in regulation of protein degradation and recycling of ubiquitin. USP14 consists of a Ubl domain connected to a USP domain via a flexible linker. LÄS MER

  4. 3. Identification and functional characterization of Epstein-Barr virus-encoded deconjugases

    Författare :Sebastian Hildebrand; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The post-translational conjugation or deconjugation of proteins by ubiquitin (Ub) or ubiquitin-like molecules (UbLs: e.g. SUMO, NEDD8, ISG15) has emerged as a major regulatory mechanism of various cellular activities. LÄS MER

  5. 4. To degrade or not to degrade : protein handling by the proteasome

    Författare :Christian Heinen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The proteasome, a large multi-subunit protease that degrades proteins, must be able to distinguish between substrates deemed for destruction and accessory proteins that should be spared. The shuttle factor Rad23 operates in close proximity to the proteasome in order to deliver proteins for their degradation. LÄS MER

  7. 5. Standards-based application integration for business-to-business communications

    Författare :Yuxiao Zhao; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Internetprogramming; Electronic ceommerce; Computer science; Datavetenskap;

    Sammanfattning : Fierce competitions and pursuits of excellence require all applications, internal or external, to be integrated for business-to-business communications. Standards play an important role in fulfilling the requirement. LÄS MER