Sökning: "Tumour size"

Visar resultat 16 - 20 av 103 avhandlingar innehållade orden Tumour size.

  1. 16. Prognostic factors in breast cancer with a focus on the role of tumour proliferation

    Författare :Claudette Falato; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Ki67 is the most commonly used marker of proliferation in breast cancer. The general aim of the thesis was to investigate the prognostic role of Ki67 and its interplay with other prognostic factors in breast cancer cohorts. LÄS MER

  3. 17. Optimizing the magnetic tracer technique for sentinel lymph node detection and tumour localization in breast cancer surgery

    Författare :Allan Jazrawi; Andreas Karakatsanis; Staffan Eriksson; Fredrik Wärnberg; Jonas Manjer; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast Cancer; Sentinel Node; Super paramagnetic ironoxide nanoparticles; SPIO; Skin Staining; Magnetic resonance imaging; magnetic seed; guidewire; Kirurgi; Surgery;

    Sammanfattning : Breast cancer is the most common form of cancer in women, and the primary treatment modalities are still breast-conserving surgery (BCS) and sentinel lymph node dissection (SLND) in most cases. Superparamagnetic iron oxide nanoparticles (SPIO) are gaining momentum as a tracer for sentinel lymph node detection. LÄS MER

  4. 18. High-molecular-weight insulin-like growth factor 2 : immunohistochemical, ultrastructural and biochemical findings in insulin cells under normal, diabetic, and neoplastic conditions, and its role in non-islet cell tumour hypoglycaemia

    Författare :Anders Höög; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Insulin-like growth factor-2; IGF-2; islets of Langerhans; B-granules; Diabetes Mellitus type 2; insulinoma; Goto-Kakizaki rat; haemangiopericytoma; ultrastructural immunohistochemistry; gene expression.;

    Sammanfattning : IGF-2 immunoreactive (IR) cells were identified in the normal adult pancreas of man and rat and occurred exclusively in insulin-producing cells. When frozen human pancreatic tissue was extracted and gel-size-separated, a high-molecular-weight (HMW) IGF-2 peptide could be identified. LÄS MER

  5. 19. Determination and use of radiobiological response parameters in radiation therapy optimization

    Författare :Panayiotis Mavroidis; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Radiotherapy optimization; tumour control; normal tissue complications; radiobiological treatment planning; biological models; dose-response parameters;

    Sammanfattning : Optimization of radiation therapy is critically dependent on the use of patient related information. For this reason, radiobiological models describing the dependence of tumour and normal tissue responses on the irradiated volume and the dose-time-fractionation schedule should be introduced. LÄS MER

  7. 20. Breast cancer epidemiology : influence of hormone-related factors

    Författare :Cecilia Magnusson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :breast neoplasms; incidence; prognosis; hormones; hormone replacement therapy; estrogens; progestational hormones; body size; body height; reproductive history; contraceptive agents; lactation;

    Sammanfattning : The main purpose of this thesis was to explore how hormone-related factors, including use of hormone replacement therapy and oral contraceptives, body size in different periods of life and reproductive factors, influence the risk of breast cancer. Other aims were to assess how family history of breast cancer modifies the associations between such factors and risk of the disease and how hormone replacement therapy affects tumour characteristics. LÄS MER