Sökning: "breast neoplasms"

Visar resultat 1 - 5 av 16 avhandlingar innehållade orden breast neoplasms.

  1. 1. Genetic determinants of breast cancer risk

    Författare :Jingmei Li; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Breast Neoplasms;

    Sammanfattning : The main purpose of this thesis was to identify genetic risk factors using both hypothesis-based and hypothesis-free approaches. In an attempt to identify common disease susceptibility alleles for breast cancer, we started off with a hypothesis-free approach, and performed a combined analysis of three genome-wide association studies (GWAS), involving 2,702 women of European ancestry with invasive breast cancer and 5,726 controls. LÄS MER

  3. 2. Health-Related Quality of Life and Return to Work following Breast Cancer

    Författare :Marie Høyer Lundh; Claudia Lampic; Birgitta Johansson; Karin Nordin; Christoffer Johansen; Uppsala universitet; []
    Nyckelord :breast neoplasms; quality of life; return to work; sick leave; cohort study; population-based; Oncology; Onkologi;

    Sammanfattning : Aim: The overall aim of this thesis was to study health-related quality of life (HRQoL) and return to work in the first 3 years following a breast cancer diagnosis, and to identify clinical and contextual factors associated with these outcomes.Method: The four studies were part of a population-based cohort study including women identified in the Breast Cancer Quality Register in central Sweden. LÄS MER

  4. 3. Studies of gene fusions and copy number alterations in salivary and adnexal neoplasms

    Författare :Marta Persson; Göteborgs universitet; []
    Nyckelord :cancer genetics; fusion oncogenes; chromosome translocation; MYB; NFIB; CRTC1; MAML2; salivary gland; breast; adenoid cystic carcinoma; mucoepidermoid carcinoma; hidradenoma;

    Sammanfattning : Cancer is a genetic disease caused by the accumulation of genetic changes such as mutations and chromosomal rearrangements. An increasing number of genetic studies of both hematological and solid neoplasms have shown that recurrent chromosome translocations often result in fusion oncogenes. LÄS MER

  5. 4. Selenium and Breast Cancer. Is It Protective? Epidemiologic Evidence Regarding Risk and Prognosis

    Författare :Malte Sandsveden; Kirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast neoplasms; Selenium; Epidemiology; cancer biomarkers; Single nucleotide polymophisms; Thyroid hormone receptor alpha; Dietary selenium intake; Serum selenium; Genetic Risk;

    Sammanfattning : .... LÄS MER

  7. 5. Aspects in mammographic screening : Detection, prediction, recurrence and prognosis

    Författare :Mercidyl Gelig Thurfjell; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Breast neoplasms; recurrence; Onkologi; Oncology; Onkologi; diagnostisk radiologi; Diagnostic Radiology;

    Sammanfattning : Screening mammograms comprising of 32 first round, 10 interval and 32 second round detected cancers and 46 normal were examined by an expert screener, a screening radiologist, a clinical radiologist and a computer-assisted diagnosis (CAD) system. The expert screener, screening radiologist, clinical radiologist and the CAD detected 44, 41, 34 and 37 cancers, respectively, while their respective specificities were 80%, 83%, 100% and 22%. LÄS MER