Sökning: "Toll like receptor"

Visar resultat 31 - 35 av 107 avhandlingar innehållade orden Toll like receptor.

  1. 31. Mechanisms of liver allograft rejections

    Författare :Xupeng Ge; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Liver transplantation; acute rejection; antibody; biliary epithelial cell; sinusoidal endothelial cell; cholangitis; toll-like receptor;

    Sammanfattning : Liver transplantation (M) has become a standard treatment for many end-stage liver diseases. However, acute rejections still occur in about half of the liver transplant recipients even treated with a combination of different modem immunosuppressants. LÄS MER

  3. 32. Influence of maternal allergy on the intra uterine environment and on immune functions of the neonate

    Författare :Ulrika Holmlund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Allergy; CD14; cord blood; cytokines; human placenta; IgE; Toll-like receptors;

    Sammanfattning : The prevalence of IgE mediated allergic diseases has drastically increased during the past few decades and there is no satisfactory explanation. A family history of allergic disease is clearly a strong risk factor, bin in view of the rapidity of the increase in allergy prevalence environmental factors are likely to have played a crucial role. LÄS MER

  4. 33. Experimental Chagas disease

    Författare :John Andersson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Trypanosoma cruzi; NK cells; cytotoxicity; IFN-gamma; IL-12; IFN-alpha beta; Chagas disease; polymyositis; myocarditis; genotype dependence and Toll-like receptors.;

    Sammanfattning : The main focus of this thesis was to develop and utilise experimental models using the protozoan parasite Trypanosoma cruzi. We were especially interested in studying the activation of NK cells early after T. cruzi infection and what factors that predispose to a chronic inflammatory disease after T. cruzi infection. LÄS MER

  5. 34. Immune regulation of herpes simplex virus type 2 infection: Special emphasis on the transcription factor T-bet

    Författare :Alexandra Svensson; Göteborgs universitet; []
    Nyckelord :HSV-2; T-bet; Substance P; Neurokinin 1; IFN-alfa beta signaling; Polymorphisms;

    Sammanfattning : Herpes simplex virus type 2 (HSV-2) is a sexually transmitted pathogen that infects the genital tract mucosa as well as local sensory neurons. It is the most common cause of genital ulcer disease in humans. The infection gives rise to a wide range of symptoms, ranging from severe and painful recurrent episodes of genital herpes to silent infection. LÄS MER

  7. 35. Studies of high mobility group chromosomal protein 1 as a pro-inflammatory cytokine

    Författare :Gail E Mullins; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HMGB1; endothelial cells; pro-inflammatory; cytokine; RAGE;

    Sammanfattning : High mobility group box chromosomal protein 1 (HMGB 1) is a nuclear protein recently recognised as a pro-inflammatory cytokine with implications both in acute and in chronic inflammation. HMGB1 has been reported to act as a late mediator of septic shock in mice. LÄS MER