Sökning: "TNF-α"

Visar resultat 36 - 40 av 203 avhandlingar innehållade ordet TNF-α.

  1. 36. Detecting the Vulnerable Plaque

    Författare :Andreas Edsfeldt; Kardiovaskulär forskning - immunitet och ateroskleros; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Atherosclerosis; Carotid plaque; Inflammation; Diabetes; LpPLA2; suPAR; Cytokines; Lipids;

    Sammanfattning : Myocardial infarction and stroke, mainly caused by a rupture of an atherosclerotic plaque, are two of the most common causes of mortality and morbidity in the world. Previous studies have pointed out inflammation, driven by inflammatory lipids, as the keystone in the formation of the rupture prone vulnerable plaque. LÄS MER

  3. 37. Effects of polyomavirus T antigens on cellular signal transduction pathways

    Författare :Karin Söderbärg; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Biokemi; Biochemistry; Biokemi; Medical Virology; medicinsk virologi;

    Sammanfattning : The early viral proteins, the tumor (T) antigens, of mouse polyomavirus,stimulate cell growth by interaction with cellular growth regulating proteins.The viral interference with cellular growth regulation may, eventually, alsoresult in effects on cellular apoptosis (programmed cell death) mechanisms. LÄS MER

  4. 38. Calcium metabolism and cytokines in critical illness

    Författare :Fredrik Carlstedt; Uppsala universitet; []
    Nyckelord :Medical sciences; calcium; critical illness; hemodynamics; hypocalcemia; IL-6; mortality; TNF-alpha; severity of disease; sepsis; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medicine; medicin;

    Sammanfattning : Hypocalcemia is a common finding in critically ill patients, particularly in those with sepsis, and has been found to be associated with increased mortality. The pathogenesis of this altered calcium metabolism is unknown and the effects of calcium supplementation are poorly investigated. LÄS MER

  5. 39. Modulating Organ Dysfunction in Experimental Septic Shock : Effects of Aminoglycosides, Antiendotoxin Measures and Endotoxin Tolerance

    Författare :Markus Castegren; Jan Sjölin; Claes Frostell; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Lipopolysaccharide; animal model; pig; tobramycin; endotoxin elimination; immunoparalysis; secondary sepsis; Infectious diseases; Infektionssjukdomar; Infektionssjukdomar; Infectious Diseases;

    Sammanfattning : Sepsis is a common diagnose in the intensive care population, burdened with a high mortality. The systemic inflammatory reaction underlying the development of septic organ dysfunction can be modeled using Gram-negative bacterial lipopolysaccharide, endotoxin. LÄS MER

  7. 40. On the biological response to different biomaterials under normal and irradiated conditions

    Författare :Louise Rydén; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; biomaterials; bone; fibrosis; hydroxyapatite; inflammation; irradiation; Osseointegration; silicone; soft tissue; titanium;

    Sammanfattning : There are several challenges when introducing an implant into a host. Concerning soft tissues, major complications are fibrosis and capsule contracture, whereas for bone, failure of osseointegration may occur. LÄS MER