Sökning: "TFR"

Visar resultat 16 - 20 av 27 avhandlingar innehållade ordet TFR.

  1. 16. Oxidative stress and alterations in the mammalian iron metabolism : A study on iron, inflammation, oxidative stress and neurodegeneration

    Författare :Jonas Hälldin; Tiit Land; Paolo Arosio; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurochemistry; Neurokemi; Neurochemistry and Molecular Neurobiology; neurokemi med molekylär neurobiologi;

    Sammanfattning : Iron is essential for all living organisms, from bacteria to man for a broad variety of biological functions, including oxygen transport and DNA synthesis. However, iron can also be toxic, due to its involvement in the formation of highly reactive oxygen species through Fenton chemistry. LÄS MER

  3. 17. Non-canonical ATG8 conjugation in ESCRT-driven membrane remodeling processes

    Författare :Anastasia Knyazeva; Yao-Wen Wu; Richard Lundmark; Sascha Martens; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; ATG8 conjugation; Endosomal Sorting Complex Required for Transport; membrane remodeling; chemical genetics;

    Sammanfattning : ATG8 family proteins have the unique ability to conjugate to membrane lipids. Initially identified as a hallmark of autophagy, ATG8 lipidation is emerging as an important regulator of a growing list of non-degradative cellular functions. LÄS MER

  4. 18. Visualising neurodegeneration in the living brain : Preclinical evaluation of PET radioligands

    Författare :Mengfei Xiong; Stina Syvänen; Sahar Roshanbin; Joakim Bergström; Per Borghammer; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Positron emission tomography PET ; Alzheimer s disease; Parkinson s disease; SV2A; neurodegeneration; immunotherapy; transgenic mice; Medicinsk vetenskap; Medical Science; Analytical Chemistry; Analytisk kemi; Pharmacology; Farmakologi; Molekylär medicin; Molecular Medicine;

    Sammanfattning : With an ageing population, the number of people suffering from Alzheimer’s disease (AD) and Parkinson’s disease (PD) escalates yearly. Pathological hallmarks of AD and PD include aggregated proteins and synaptic dysfunction. LÄS MER

  5. 19. Cellular and molecular factors in the pathogenesis of systemic autoimmunity and comorbidities

    Författare :Margarita Ivanchenko; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Sjögren’s syndrome (SS) and systemic lupus erythematosus (SLE) are systemic rheumatic autoimmune diseases having a major impact on patient’s wellbeing. Besides fatigue, pain and direct damage to exocrine glands in SS, and various target organs, such as skin, joints, kidneys and brain in SLE, these diseases confer an increased risk of lymphoma development and can cause an autoimmune condition in the foetus of pregnant patients, termed neonatal lupus. LÄS MER

  7. 20. One-click away from higher contrast : Improvements to peripheral clearance for same-day immunoPET in Alzheimer’s disease

    Författare :Eva Schlein; Dag Sehlin; Jordi Llop Roig; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer’s disease AD ; bispecific antibody; Amyloid-β Aβ ; Receptor mediated transcytosis RMT ; Neonatal Fc receptor FcRn ; Blood-brain barrier BBB ; Inverse electron demand Diels−Alder reaction IEDDA; pre-targeting; tetrazine; bio-orthogonal; Fluorine-18; clearing agent;

    Sammanfattning : The brain is a challenging target for antibody-based positron emission tomography (immunoPET) to image amyloid-beta (Aβ). Antibodies detect pathology with high sensitivity, but due to their size and biological half-life, they cause a high background radiation, if radiolabelled. LÄS MER