Sökning: "Susanna Ekholm-Reed"

Hittade 1 avhandling innehållade orden Susanna Ekholm-Reed.

1. 1. The role of cyclin E in cell cycle regulation and genomic instability

   Författare :Susanna Ekholm-Reed; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Cyclin E; cell cycle; Restriction point; pre-RC; Mcm proteins; DNA replication; tumorigenesis; proteolysis; hCdc4;

   Sammanfattning : Cyclin E, a positive regulatory subunit of Cdk2, normally accumulates periodically at the G1/S transition, where it promotes entry into S phase and other DNA replication-associated functions. However, in many types of human cancer, cyclin E is overexpressed and in some cases its expression becomes deregulated, a phenomenon generally associated with poor prognosis. LÄS MER