Sökning: "polyketide"

Visar resultat 1 - 5 av 7 avhandlingar innehållade ordet polyketide.

  1. 1. Polyketide production in Alternaria alternata : effects of light and nitrogen

    Författare :Maria Hiltunen; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP;

    Sammanfattning : .... LÄS MER

  3. 2. Structural enzymology of the biosynthesis of polyketide antibiotics

    Författare :Anna Jansson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :X-ray crystallography; anthracycline; polyketide; Streptomyces; S-adenosyl-Lmethionine; methyltransferase; hydroxylase; aldol-condensation.;

    Sammanfattning : Anthracyclines are an important group of aromatic antibiotics that exhibit antitumour activity, which makes them useful in treatment of various cancers. They are synthesised in the polyketide biosynthetic pathway as secondary metabolites by different Streptomyces species. LÄS MER

  4. 3. Mechanistic insights into the biosynthesis of polyketide antibiotics

    Författare :Azmiri Sultana; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Anthracyclines are a group of aromatic polyketide compounds with significant medical importance due to their antineoplastic properties. Doxorubicin and daunorubicin members of this family are among the two most commonly used anticancer drugs. However, these compounds exhibit severe side effects like cardiotoxicity and multi-drug resistance. LÄS MER

  5. 4. Enzymatic activation of oxygen in the biosynthesis of polyketide antibiotics

    Författare :Hanna Koskiniemi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The electron structure of molecular oxygen (O2) is such that it cannot spontaneously react with organic molecules, a feature that protects organisms from oxidative stress. However, oxygenases can insert O2 in organic substrates. The enzymes do this after activating O2 for the reaction, most often with the aid of an organic or inorganic cofactor. LÄS MER

  7. 5. Polyketide production in fungi, the effect of light and substrates

    Författare :Per Häggblom; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP;

    Sammanfattning : .... LÄS MER