Sökning: "Mcm proteins"

Hittade 4 avhandlingar innehållade orden Mcm proteins.

  1. 1. Modulation of nuclear receptor function by interacting proteins

    Författare :Waffa Osman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Nuclear receptors are a family of transcription factors involved in many biological processes. They represent key potentials as therapeutic targets for several clinical conditions such as diabetes, obesity, cardiovascular disease and cancer, because their activity is modulated by small molecules. LÄS MER

  3. 2. The role of cyclin E in cell cycle regulation and genomic instability

    Författare :Susanna Ekholm-Reed; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Cyclin E; cell cycle; Restriction point; pre-RC; Mcm proteins; DNA replication; tumorigenesis; proteolysis; hCdc4;

    Sammanfattning : Cyclin E, a positive regulatory subunit of Cdk2, normally accumulates periodically at the G1/S transition, where it promotes entry into S phase and other DNA replication-associated functions. However, in many types of human cancer, cyclin E is overexpressed and in some cases its expression becomes deregulated, a phenomenon generally associated with poor prognosis. LÄS MER

  4. 3. Discovering circulating protein biomarkers through in-depth plasma proteomics

    Författare :Haris Babačić; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Plasma, i.e., the liquid component of blood, is one of the most clinically used samples for biomarker measurement. LÄS MER

  5. 4. Mammalian cell cycle regulation : characterisation of three genes expressed in proliferating cells

    Författare :Maria Starborg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Cell cycle; DNA replication; licensing factor; mitosis; ceheckpoint regulator; centromere regions; cell proliferation marker; nucleolar protein; spermatogenesis;

    Sammanfattning : Proliferating cells undergo different phases in their life cycle. During interphase the cells grow and duplicate their DNA content, followed by a cell division phase, mitosis, which results in two daughter cells. LÄS MER