Sökning: "Structural Elucidation"

Visar resultat 21 - 25 av 57 avhandlingar innehållade orden Structural Elucidation.

  1. 21. Structural and functional studies of factor V in health and disease

    Författare :Mårten Steen; Malmö Klinisk kemi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Klinisk kemi; Clinical chemistry; APC resistance and hemophilia; thrombosis; factor VIII; coagulation; factor V;

    Sammanfattning : The homologous blood coagulation factors V (FV) and factor VIII (FVIII) are important at sites of vascular injury for the amplification of the clotting cascade. Activated FV (FVa) serves as a cofactor to the enzyme activated factor X (FXa) in the activation of prothrombin. This complex is called the prothrombinase complex. LÄS MER

  3. 22. Molecular structure of the human skin’s barrier : elucidation, formation and utilization

    Författare :Ali Narangifard; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The main focus of this study is the permeation barrier of human skin. Original cryo-electron microscopic images from near native samples of human epidermis was used as the guiding reference to assemble in silico molecular models and also to assess the possibility of their presence in the barrier. LÄS MER

  4. 23. Secondary and Higher Order Structural Characterization of Peptides and Proteins by Mass Spectrometry

    Författare :Christopher Adams; Roman Zubarev; Göran Possnert; Carlito Lebrilla; Uppsala universitet; []
    Nyckelord :Engineering physics; Protein Structure; Mass Spectrometry; Electron Capture Dissociation; Tandem Mass Spectrometry; Teknisk fysik;

    Sammanfattning : The work in this thesis has demonstrated the advantages and limitations of using MS based technologies in protein and peptide structural studies. Tandem MS, specifically electron capture dissociation (ECD) have shown the ability to provide structural insights in molecules containing the slightest of all modifications (D-AA substitution). LÄS MER

  5. 24. Detailed structural studies towards the understanding of lipopolysaccharide glycan expression in non-typeable Haemophilus influenzae

    Författare :Susanna Lundström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Haemophilus influenzae (Hi) is a host-adapted Gram-negative bacterium that regularly colonizes the respiratory tract of humans. Hi is an important cause of disease worldwide and exists in encapsulated and unencapsulated (non-typeable, NT) forms. LÄS MER

  7. 25. Detection and Structure Elucidation of Drug Metabolites in Biological Samples using HPLC-MS/MS Techniques

    Författare :Annica Tevell Åberg; Mikael Hedeland; Ulf Bondesson; Mario Thevis; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; Farmaceutisk kemi; analytisk farmaceutisk kemi; Analytical Pharmaceutical Chemistry;

    Sammanfattning : This thesis describes the structure elucidation of drug metabolites in biological samples by the use of high performance liquid chromatography (HPLC) atmospheric pressure ionization (API) tandem mass spectrometry (MS/MS). Due to their different advantages, various mass analyzers have been used in the different experiments. LÄS MER