Sökning: "Marcus Ruda"

Hittade 1 avhandling innehållade orden Marcus Ruda.

1. 1. Design and synthesis of steroid mimetic libraries using solid phase techniques

   Författare :Marcus Ruda; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Pyridone; quinolone; benzoindazole; solid phase chemistry; scavenger resin; combinatorial chemistry; alpha-arylation; nuclear hormone receptor; steroid mimetic.;

   Sammanfattning : This thesis deals with the design and synthesis of biologically active ligands for nuclear hormone receptors using combinatorial techniques. In the first part, a 5,6,6a,7,8,9,10,10a-octahydrobenzo[f]quinolin-3(4H)-one tricyclic core structure was designed mimicking the ABC-rings of a steroid. LÄS MER