Sökning: "posttranslational"

Visar resultat 1 - 5 av 83 avhandlingar innehållade ordet posttranslational.

1. 1. A New Look into Protein C Inhibitor : Posttranslational Modifications and their Functions

   Författare :Wei Sun; Sophia Schedin Weiss; Hakon Leffler; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Protein C inhibitor; posttranslational modifications; N-glycan; O-glycan; mass spectrometry; factor Xa; thrombin; prostate specific antigen; Biochemistry; Biokemi; Biokemi; Biochemistry;

   Sammanfattning : The influences of posttranslational modifications on the functions of the versatile serpin protein C inhibitor (PCI) were studied. PCI is a serine protease inhibitor that is expressed in many tissues and secreted to various fluids in human, including blood plasma, seminal plasma, and urine. LÄS MER

3. 2. Studies of Eosinophil Cationic Protein (ECP) in vivo and in vitro : Impact of Genetic and Posttranslational Modifications

   Författare :Jenny Eriksson; Per Venge; Agneta Trulson; Ester Boix; Uppsala universitet; []
   Nyckelord :Biomedicine; Eosinophil granulocyte; granular protein; ECP; gene polymorphism; cytotoxicity; SELDI-TOF MS; glycosylation; molecular and functional heterogeneity; fibrosis; Biomedicin;

   Sammanfattning : Eosinophil granulocytes are tissue dwelling leukocytes that are implicated in host defence, particularly against helminthic parasites; they also participate in most inflammatory disorders. Although eosinophils have important roles in host defence mechanisms, their actions can also be harmful to the host as in the allergic inflammation where lung epithelium is destructed due to the release of toxic granule proteins. LÄS MER

4. 3. Tec family kinases : transcriptional and posttranslational regulation

   Författare :Liang Yu; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Tec family tyrosine kinases consist of five members: Btk, Itk, Tec, Rlk/Txk and Bmx. These kinases are highly expressed in hematopoietic cells, including B cells, T cells and mast cells. LÄS MER

5. 4. Modulation of PDGF receptors function by posttranslational modifications

   Författare :Kehuan Wang; Carl-Henrik Heldin; Johan Lennartsson; Natalia Papadopoulos; Jean-Baptiste Demoulin; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PDGF signaling; receptor tyrosine kinase; ubiquitination; DUB; STAT3; SUMO; SUMOylation; cleavage; autophagy; SQSTM1 p62; LC3; GABARAP; bafilomycin A1; Medicinsk biokemi; Medical Biochemistry; Medical Cell Biology; Medicinsk cellbiologi;

   Sammanfattning : The platelet-derived growth factor receptors (PDGFRs) play important roles in multiple cellular processes including cell survival, cell growth and cell migration. Dysregulation of PDGFRs causes aberrant PDGF signaling, which leads to various diseases. LÄS MER

7. 5. Evolutionary Analysis and Posttranslational Chemical Modifications in Protein Redesign : A Study on Mu Class Glutathione Transferases

   Författare :Ylva Ivarsson; Bengt Mannervik; Gun Stenberg; Richard N. Armstrong; Uppsala universitet; []
   Nyckelord :Biochemistry; glutathione transferase; evolutionary analysis; positive selection; epoxide; stereoselectivity; protein modification; Biokemi;

   Sammanfattning : Glutathione transferases (GSTs) constitute a family of multifarious enzymes that conjugate glutathione (GSH) with a wide range of electrophiles. GSTs are grouped into different classes based on protein sequence similarities. Despite high sequence identities between GSTs of the same class they often display different substrate specificites. LÄS MER