Sökning: "combinatorial chemistry"

Visar resultat 1 - 5 av 25 avhandlingar innehållade orden combinatorial chemistry.

  1. 1. Dynamic Sulfur Chemistry : Screening, Evaluation and Catalysis

    Författare :Rémi Caraballo; Olof Ramström; Nicolas Giuseppone; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Dynamic combinatorial chemistry; dynamic sulfur chemistry; thioglycoside; mutarotation; disulfide metathesis; hemithioacetal formation; 1H STD-NMR; inhibition; phosphine; Concanavalin A; beta-galactosidase; dynamic drug discovery.; Chemistry; Kemi; Organic chemistry; Organisk kemi; Bioorganic chemistry; Bioorganisk kemi;

    Sammanfattning : This thesis deals with the design, formation and evaluation of dynamic systems constructed by means of sulfur-containing reversible reactions, in organic and aqueous media and under mild conditions. In a first part, the synthesis of thioglycoside derivatives, constituting the biologically relevant starting components of the dynamic systems, is described. LÄS MER

  3. 2. Discovery-Oriented Screening of Dynamic Systems: Combinatorial and Synthetic Applications

    Författare :Marcus Angelin; Olof Ramström; Stefan Kubik; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; chemical education; crystallization; dynamic combinatorial chemistry; dynamic combinatorial resolution; dynamic system; enzyme catalysis; isoindolinone; lipase; nitroalcohol; nitroaldol reaction; phthalide; reversible; secondary alcohol; systems chemistry; tandem reaction; Organic chemistry; Organisk kemi; Bioorganic chemistry; Bioorganisk kemi;

    Sammanfattning : This thesis is divided into six parts, all centered around the development of dynamic (i.e., reversibly interacting) systems of molecules and their applications in dynamic combinatorial chemistry (DCC) and organic synthesis. LÄS MER

  4. 3. Catalysis in Dynamic Systems: Control within Molecular Reaction Networks

    Författare :Fredrik Schaufelberger; Olof Ramström; Leonard Prins; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; systems chemistry; dynamic covalent chemistry; catalyst screening; reaction networks; organocatalysis; imine exchange; combinatorial chemistry; dynamic systemic resolution; feedback; error-correction; Morita-Baylis-Hillman reaction; C-H activation; H-bond catalysis; transamination; Kemi; Chemistry;

    Sammanfattning : Life as we know it is based on complex networks of biochemical reactions that constantly interact within large dynamic systems. The field of systems chemistry uses chemical models to study how reaction networks – and thereby life – function on a molecular level. LÄS MER

  5. 4. Combinatorial Synthesis of Pilicides

    Författare :Anette Svensson; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; gel-phase 19F NMR spectroscopy; fluorinated linkers; E. coli bacteria; pilicides; combinatorial chemistry; solid-phase synthesis; Organic chemistry; Organisk kemi;

    Sammanfattning : This thesis describes a combinatorial approach to design and synthesis of three libraries of compounds, referred to as pilicides, designed to target periplasmic chaperones present in uropathogenic Escherichia coli bacteria that are the main cause of urinary tract infections. Periplasmic chaperones are required for assembly of adhesive organelles, i. LÄS MER

  7. 5. Fast Chemistry by Microwave Heating : First Descriptions of Highly Enantioselective Microwave Protocols for Metal Catalysis; First Descriptions of in-situ Gas Generation for Fast Combinatorial Microwave Chemistry

    Författare :Nils-Fredrik K. Kaiser; C. O.; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi; Organic Pharmaceutical Chemistry; organisk farmaceutisk kemi;

    Sammanfattning : Microwave heating was applied to different palladium-catalyzed allylic substitution reactions. The use of various nucleophiles demonstrated C-, N-, O- and S- nucleophilicity. High yields and stereopurities of the corresponding alkyls, amides, ethers and sulfones were afforded after only 30 – 120 s of heating. LÄS MER