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Visar resultat 21 - 25 av 27 avhandlingar som matchar ovanstående sökkriterier.

  1. 21. Skeletal muscle calcium homeostasis during fatigue : modulation by kinases and mitochondria

    Författare :Jan Aydin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The use of skeletal muscles in daily activities and even during strenuous exercise resulting in fatigue requires precise regulation of force and the timing of contraction. To achieve such performance characteristics, vertebrate skeletal muscles have developed a unique control mechanism for regulating the free Ca2+ concentration in their myoplasm ([Ca2+]i). LÄS MER

  3. 22. Infrared spectroscopic studies : from small molecules to large

    Författare :Nadejda Eremina; Andreas Barth; Silvia Maria Doglia; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Infrared spectroscopy; transcription factors; DNA; creatine kinase; CaATPase; water; ligand binding; biofarmaci; Biopharmaceutics;

    Sammanfattning : Infrared light (IR) was first discovered by Friedrich Wilhelm Herschel in 1800. However, until 1940’s, molecular IR studies involved only water and small organic molecules, because of the long measurement times. LÄS MER

  4. 23. Mathematical aspects of apolipoprotein kinetics, with focus on metabolic diseases

    Författare :Valentina Fermanelli; Chalmers tekniska högskola; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; apoA4; apolipoproteins; abdominal obesit; type II diabetes; NLMEM; apoC-III; mathematical modelling; apoE;

    Sammanfattning : Biomathematics is a branch of science that aims at describing biological processes in mathematical terms to frame and solve otherwise unsolvable research questions in the biological and medical field. Cardiovascular diseases are the number one cause of death in the world. LÄS MER

  5. 24. Peptide-based delivery to glioblastoma cells studied by the blood-brain barrier model

    Författare :Artita Srimanee; Ülo Langel; Ing-Marie Nilsson; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; peptide-based delivery; blood-brain barrier; glioblastoma; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Sammanfattning : Crossing the blood-brain barrier (BBB) is a great challenge for delivery of highly charged macromolecules such as nucleic acids and proteins to the brain. Cell-penetrating peptides (CPPs) are promising vectors to deliver various cargoes ranging from small molecules to large molecules such as antibodies, proteins, and nucleic acids. LÄS MER

  7. 25. On enhancement of bone formation using local drug delivery systems

    Författare :Ali Alenezi; Ann Wennerberg; Malmö universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; bone formation; local drug delivery systems;

    Sammanfattning : Introduction: Despite that many reports have confirmed the long-term clinical success rates associated with implant treatment, implant failure to achieve and maintain osseointegration still occurs in many cases. Local and sustained drug release at the bone-implant interface is one of the strategies that have been suggested to improve the osseointegration. LÄS MER