Sökning: "RNA and protein correlation"

Visar resultat 6 - 10 av 66 avhandlingar innehållade orden RNA and protein correlation.

1. 6. Omics Data Analysis of Complex Diseases and Traits

   Författare :Saman Hosseini Ashtiani; Arne Elofsson; Dirk Repsilber; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Omics data; RNA-seq; Microarrays; Metabolomics; Network analysis; Psoriasis; E. coli; Hip osteoporosis; Lung adenocarcinoma; Spearman s correlation coefficient; LC-MS; PCA; DEG; PPI; biokemi med inriktning mot bioinformatik; Biochemistry towards Bioinformatics;

   Sammanfattning : Following the advent of the high-throughput techniques for producing massive omics data, new possibilities and challenges have also emerged in different fields of biology and medicine. Dealing with such data on different scales with different scopes such as genomics, transcriptomics, proteomics and metabolomics, demands appropriate data collection, preprocessing, statistical analysis, interpretation and visualization. LÄS MER

3. 7. The Role of RNA Binding Proteins in Insulin Messenger Stability and Translation

   Författare :Rikard G. Fred; Nils Welsh; Michele Solimena; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medical cell biology; Medicinsk cellbiologi; Medical Cell Biology; Medicinsk cellbiologi;

   Sammanfattning : Although the reason for insufficient release of insulin in diabetes mellitus may vary depending on the type and stage of the disease, it is of vital importance that an amplified insulin biosynthesis can meet the increased need during periods of hyperglycemia. The insulin mRNA is highly abundant in beta cells and changes in insulin mRNA levels are, at least in part, controlled by altered rates of mRNA degradation. LÄS MER

4. 8. p63 – from expression to function : studies of normal oral mucosa and squamous cell carcinoma of the head and neck

   Författare :Niklas Thurfjell; Karin Nylander; Phillip Coates; Göran Roos; Luisa Guerrini; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; p63; SCCHN; p53; BRCA1; Pathology; Patologi;

   Sammanfattning : The human p63 gene discovered in 1997 encodes a series of protein isoforms that differ in their N- and/or C-terminal sequences. These isoforms have widely differing properties in promoting or repressing p53-related functions such as growth arrest and apoptosis. LÄS MER

5. 9. Dissecting the role of micro-RNAs in diabetes

   Författare :Caroline Bolmeson; Create Health; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 1 diabetes; Type 2 diabetes; micro-RNA; Dicer; beta-cell function; insulin secretion; glucose; NOD mouse; Goto-Kakizaki rat; human islets; thymocytes; apoptosis;

   Sammanfattning : The role of miRNAs in pancreatic islets and β-cell function and in the development of diabetes in human and rodents have been investigated in this thesis. Dicer1 was specifically deleted in vivo in pancreatic β-cells under the RIP-promoter in mice. LÄS MER

7. 10. Squamous cell carcinoma of the oral tongue : studies of biomarkers connected to human papillomavirus infection, epithelial to mesenchymal transition and locoregional metastatis

   Författare :Nicola Sgaramella; Karin Nylander; Karin Danielsson; Giuseppe Colella; Robin Fåhraeus; Lorenzo Lo Muzio; George Sekine; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; squamous cell carcinoma oral tongue; p16; HPV; podoplanin; E-cadherin; patologi; Pathology;

   Sammanfattning : Background: Oral Tongue Squamous Cell Carcinoma (OTSCC) is the most frequent and aggressive carcinoma in the head and neck region. Its incidence has increased during the last decades, especially in young patients (≤40 years) mainly female. LÄS MER