Sökning: "RNA Therapeutics"

Visar resultat 1 - 5 av 33 avhandlingar innehållade orden RNA Therapeutics.

  1. 1. Extracellular Vesicles and RNA interference in tumors

    Författare :Taral R Lunavat; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Melanoma; Therapeutics; Exosome-mimetic nanovesicles; Apoptotic bodies; Microvesicles; Exosomes;

    Sammanfattning : Extracellular vesicles (EVs) including apoptotic bodies (ABs), microvesicles (MVs), exosomes (EXOs) and cell derived artificial nanovesicles (NVs) are important mediators of cell-to-cell communication, in part by transferring bioactive molecules such as DNA, mRNA, miRNA, siRNA, proteins, and lipids. These EVs are released by many cell types, including melanoma cells, and are found in many body fluids. LÄS MER

  3. 2. Detection and quantification of lipid-mediated siRNA delivery to the cytosol

    Författare :Hampus Hedlund; Tumörmikromiljö; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; RNA Interference; RNA Therapeutics; Endosomal Escape; Lipid Mediated Delivery; Live-Cell Imaging;

    Sammanfattning : Cancer is one of the leading causes of death globally. Novel therapeutics is urgently needed to advance treatment, especially for generalized disease where current treatment options have a poor prognosis. In particular, targeted therapy that can address genetic changes would be of great value. LÄS MER

  4. 3. Development of immunomodulatory RNA therapeutics for immune disorders

    Författare :Vaishnavi Srinivasan Iyer; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Autoimmune diseases such as Rheumatoid Arthritis (RA) are complex and involve many different cell types. Of these cell types, T cells are thought to be key drivers of the inflammation. LÄS MER

  5. 4. Conformationally Constrained Nucleic Acids as Potential RNA Targeting Therapeutics

    Författare :Zhou Chuanzheng; Jyoti Chattopadhyaya; Serge Beaucage; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Bioorganic chemistry; Bioorganisk kemi; Chemistry with specialization in Bioorganic Chemistry; Kemi med inriktning mot bioorganisk kemi;

    Sammanfattning : .... LÄS MER

  7. 5. Design and application of RNA therapeutics for splice site mutations

    Författare :Burcu Bestas; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Precursor messenger RNA splicing is one of the most fundamental and complex mechanisms in eukaryotes. Over 90% of the human genes undergo alternative splicing, which is essential for the regulation of gene expression. A dynamic RNA-protein complex called the spliceosome catalyzes splicing. LÄS MER