Sökning: "R6 2 mouse"

Hittade 5 avhandlingar innehållade orden R6 2 mouse.

  1. 1. Energy metabolism as a target for new treatment strategies in Huntington’s disease

    Författare :Marie Sjögren; Biomarkörer vid hjärnsjukdomar; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Huntington´s disease; Energy metabolic alteration; Weight loss; Skeletal muscle; Adipose tissue; R6 2; Ghrelin; Liraglutide;

    Sammanfattning : Huntington´s disease (HD) is a fatal inherited neurodegenerative disorder caused by a CAG triplet repeat expansion in the huntingtin (HTT) gene and characterized by cognitive and motoric dysfunctions as well as psychiatric problems. Accumulating evidence, however, suggests altered energy metabolism and a hyper-catabolic state as key features of HD pathology. LÄS MER

  3. 2. β-cell dysfunction in Huntington's disease

    Författare :Karl Bacos; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; metabolism; secretion; Insulin; trafficking; R6 2 mouse; granule; exocytosis; neurodegeneration; huntingtin;

    Sammanfattning : Huntington's disease (HD), a fatal neurodegenerative disorder, is associated with an increased risk of diabetes mellitus. The reason for this is unknown, but considering the functional similarities of neurons and the insulin secreting pancreatic β-cell, pathological mechanisms may be shared by both cell types and account for neuronal as well as endocrine dysfunction. LÄS MER

  4. 3. Brown is the new white: consequences of white adipose tissue alterations in Huntington's disease

    Författare :Andy Mccourt; Biomarkörer vid hjärnsjukdomar; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Huntington’s disease; weight loss; white adipose tissue; brown adipose tissue; peripheral symptoms; R6 2 mice; UCP1; CREB1; gene expression;

    Sammanfattning : Huntington's disease (HD) is a devastating, inherited neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin gene. Peripheral symptoms, such as skeletal muscle wasting, progressive weight loss, altered body composition and endocrine disturbances exist alongside neurodegeneration. LÄS MER

  5. 4. Neuronal Cell Death and Restoration in the Basal Ganglia: Implications for Huntington's and Parkinson's diseases

    Författare :Oskar Hansson; Neurobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; basal ganglia; Parkinson s disease; Huntington s disease; neural transplantation; restoration; NMDA receptor; excitotoxicity; calcium; caspase; neuronal cell death; apoptosis; transgenic mouse; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

    Sammanfattning : Huntington's disease (HD) is a hereditary neurodegenerative disorder presenting with chorea, dementia and extensive striatal neuronal death. The mechanism through which the widely expressed mutant huntingtin mediates striatal neurotoxicity is unknown. Excitotoxicity, i.e. LÄS MER

  7. 5. Insight into the genetic characteristics of pneumococcal isolates

    Författare :Christel Blomberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Streptococcus pneumoniae is a human pathogen and a major contributor to morbidity and mortality worldwide. It has been estimated that it is responsible for between 1-2 million deaths annually. The normal niche for the pneumococci is the nasopharynx where the bacteria can residue for months without causing any symptoms. LÄS MER