Sökning: "Proinsulin"

Visar resultat 16 - 20 av 48 avhandlingar innehållade ordet Proinsulin.

  1. 16. Tracer development and PET studies : labeled proinsulin C-peptide and an EGFR-TK inhibitor

    Författare :Anna Fredriksson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :PET; imaging; kinetics; oncology; EGFR; PD153035; diabetes; C-peptide;

    Sammanfattning : Positron emission tomography (PET), which localizes and quantifies positron decays over time, enables non-invasive in vivo distribution studies of trace amounts of compounds labeled with positron emitters. The use of PET to image disease processes is growing as the number of available tracers increases and, especially, as they become more selective and specific. LÄS MER

  3. 17. C-peptide structural and functional relationships studied by biosensor technology and mass spectrometry

    Författare :Ermias Melles; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Proinsulin C-peptide; biosensor; mass spectrometry;

    Sammanfattning : Proinsulin C-peptide has a number of biological activities and receives interest focusing on the therapeutic potential as a candidate for future co-replacement therapy with insulin in type 1 diabetes. Based on conservation results from comparisons of 22 mammalian proinsulin variants, analogs were constructed for studies of phosphorylation of mitogenactivated protein kinases (MAPKs) in Swiss 3T3 fibroblasts. LÄS MER

  4. 18. Mechanisms and effects of low plasminogen activator inhibitor type 1 activity

    Författare :Anna Ågren; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Bleeding; body mass index; epidemiology; plasminogen activator inhibitor; surgery; prostate; fibrinolysis; C-peptide; CRP; IL-6; proinsulin;

    Sammanfattning : Bleeding diathesis is a common reason for investigation of the haemostatic system and in about 50% of the cases an abnormality is found. Plasminogen activator inhibitor type 1 (PAI-1) is an inhibitor of tissue- and urokinase plasminogen activator (tPA/uPA). LÄS MER

  5. 19. Endocrine aspects of obesity and weight reduction by bariatric surgery : with special emphasis on beta cell function

    Författare :Marie Guldstrand; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Obesity; weight reduction; b ariatric surgery; insulin; glucagon; type 2 diabetes; insulin sensitivity; HPA axis; autonomic nervous system ANS ; cognitive functions; proinsulin; GIP; GLP-1; IGFBP- 1; diazoxide;

    Sammanfattning : Severe obesity is the most predictive acquired risk factor for the development of type 2 diabetes. Bariatric surgery induces marked weight loss and reverses the diabetic state significantly. LÄS MER

  7. 20. Clinical Manifestations of Coronary Heart Disease and the Metabolic Syndrome : A Population-based Study in Middle-aged Men in Uppsala

    Författare :Kristina Dunder; Lars Lind; Hans Lithell; Annika Rosengren; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; coronary heart disease; metabolic syndrome; insulin resistance; antihypertensive treatment; risk score; Medicin; Dermatology and venerology; clinical genetics; internal medicine; Dermatologi och venerologi; klinisk genetik; invärtesmedicin;

    Sammanfattning : During the past decades the knowledge concerning risk factors and pathophysiology of coronary heart disease (CHD) has substantially increased. However, despite identification of important risk factors CHD remains the leading cause of death in the western world. LÄS MER