Sökning: "Peter Hellman"
Visar resultat 1 - 5 av 9 avhandlingar innehållade orden Peter Hellman.
1. Small Intestinal Neuroendocrine Tumor : A Rare Malignancy with Favorable Outcome
Sammanfattning : Small intestinal neuroendocrine tumor (SI-NET) is the most common small bowel tumor in Europe and USA, with an annual incidence of around 0.3-1.3/100000 persons. LÄS MER
2. Human dendritic cells : a study of early events during pathogen recognition and antigen endocytosis
Sammanfattning : The mononuclear phagocyte cell system includes monocytes, macrophages anddendritic cells which are important cells in order to recognize, ingest, destroyand also present part of a pathogen to T-lymphocytes in order to activate theadaptive immune system. Dendritic cells (DCs) stand out in their ability tostimulate T-lymphocytes and are also believed to be important to keeptolerance for “self-antigens”. LÄS MER
3. Calcium Homeostasis in Patients with Graves' Disease
Sammanfattning : Patients with Graves´ Disease (GD) have a higher risk of developing more severe and prolonged hypocalcaemia after total thyroidectomy (TT) than patients who undergo surgery for benign atoxic goitre. Since TT is the most effective treatment for GD, it is crucial to identify mechanisms for postoperative hypocalcaemia. LÄS MER
4. Molecular studies of endocrine tumors : Insights from genetics and epigenetics
Sammanfattning : Endocrine tumors may be benign or malignant and may occur in any of the hormone producing tissues. They share several biological characteristics, including a low mutation-burden, and may co-occur in several hereditary tumor syndromes. The aim of this thesis was to identify genetic and epigenetic aberrations in endocrine tumors. LÄS MER
5. Studies of epigenetic deregulation in parathyroid tumors and small intestinal neuroendocrine tumors
Sammanfattning : Deregulation of the epigenome is associated with the initiation and progression of various types of human cancers. Here we investigated the level of 5-hydroxymethylcytosine (5hmC), expression and function of TET1 and TET2, and DNA methylation in parathyroid tumors and small intestinal neuroendocrine tumors (SI-NETs). LÄS MER