Sökning: "TET1"
Visar resultat 1 - 5 av 6 avhandlingar innehållade ordet TET1.
1. Studies of epigenetic deregulation in parathyroid tumors and small intestinal neuroendocrine tumors
Sammanfattning : Deregulation of the epigenome is associated with the initiation and progression of various types of human cancers. Here we investigated the level of 5-hydroxymethylcytosine (5hmC), expression and function of TET1 and TET2, and DNA methylation in parathyroid tumors and small intestinal neuroendocrine tumors (SI-NETs). LÄS MER
2. Exploring the dynamic epigenome in pluripotent stem cells using quantitative methods
Sammanfattning : A totipotent stem cell has the potential to give rise to the trillions of cells in the human body, all carrying the very same genetic information. Through differentiation events, gene expression changes guided by epigenetic mechanisms resulting in specialized phenotypes. LÄS MER
3. Genome-wide epigenetic profiling of B cell leukemia and lymphoma
Sammanfattning : Epigenetic modifications, at the level of DNA methylation and post-translational modifications of histone tails cooperatively function in the organization of the genome, and thereby establish the gene expression profiles, phenotypes, and cellular fates. In this work, we investigated the aberrant epigenome in chronic lymphocytic leukemia (CLL) which is one of the most frequent lymphoid malignancies in the west including the Nordic countries. LÄS MER
4. Novel mechanisms in depression: focus on telomere biology and epigenetic regulation
Sammanfattning : Depression is a complex disorder with an average lifetime prevalence from 11.1% to 14.6%. It causes serious disability and is a significant public health problem worldwide. LÄS MER
5. Alterations in proliferation and differentiation of neural stem cells induced by adverse neurodevelopmental factors
Sammanfattning : Predisposition to diseases can be acquired during early stages of development and resolve into an actual disorder later in life. Early life programming defines the association between challenges during pregnancy that result in altered fetal growth, and developmental and adult disorders. LÄS MER