Sökning: "Parallel Synthesis"

Visar resultat 11 - 15 av 117 avhandlingar innehållade orden Parallel Synthesis.

  1. 11. Synthesis of substituted Ring-Fused 2-Pyridones and applications in chemical biology

    Författare :Christoffer Bengtsson; Fredrik Almqvist; Paul Helquist; Umeå universitet; []
    Nyckelord :Synthesis; 2-pyridone; 2-thiazoline; cross coupling; pili; curli; antibacterial; organisk kemi; Organic Chemistry;

    Sammanfattning : Antibiotics have been extensively used to treat bacterial infections since Alexander Fleming’s discovery of penicillin 1928. Disease causing microbes that have become resistant to antibiotic drug therapy are an increasing public health problem. LÄS MER

  3. 12. Synthesis Towards Biologically Active Natural Products

    Författare :Rikard Larsson; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Transtaganolide; basiliolide; natural product; total synthesis; biomimetic; Thapsia; Diels-Alder; Ireland-Claisen; Pictet-Spengler; tetrahydroisoquinoline; indole;

    Sammanfattning : In 2005 two research groups independently reported the isolation of a series of structurally intriguing C-19 terpenolides from the plants Thapsia transtagana and Thapsia garganica. The compounds were shown to be potent inhibitors of the sarco/endoplasmic reticulum Ca2+-ATPases. LÄS MER

  4. 13. Synthesis and Applications of P-chirogenic Phosphine Boranes

    Författare :Magnus Johansson; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; cytisine; gold I catalysis lipase; P-chirogenic; desymmetrization; phosphine; enantioselective cyclopropanation. enantioselective deprotonation; chirality; asymmetric synthesis; borane;

    Sammanfattning : AbstractThis thesis reports the independent synthesis of both enantiomers of P-chirogenic phosphine ligands and the building blocks thereof, which are suitable for parallel synthesis efforts and for the generation of more diverse libraries of P-chirogenic compound. The use of P-chirogenic phosphine boranes in transition metal-catalyzed reactions, such as palladium-catalyzed allylic alkylation and amination, is also described. LÄS MER

  5. 14. Design & Synthesis of Protein Interacting Affinity Ligands and Protease Inhibitors

    Författare :Charlotta Lindquist; Hans Adolfsson; Fredrik Almqvist; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic synthesis; Organisk syntes; organisk kemi; Organic Chemistry;

    Sammanfattning : There is a growing need of both protein drugs and synthetic drugs in the fight against many life-threatening diseases. The first part of this thesis deals with the design and synthesis of high affinity binding ligands for the purification of protein drugs. LÄS MER

  7. 15. Electrothermal Simulation in a Concurrent Waveform Relaxation Based Circuit Simulator

    Författare :Magnus Wiklund; Institutionen för elektro- och informationsteknik; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Circuit synthesis; Bond graphs; Nullor; Circuit theory; Analog simulation; Circuit simulation; Multiprocessor computer; CONCISE; Parallel computation; Waveform relaxation; Thermal models; Transistor models; Electro-thermal simulation; Electro-thermal modeling; Translinear circuits; Electronics; Elektronik; Electrical engineering; Elektroteknik;

    Sammanfattning : The main purpose of this work is to study methods to simulate electro-thermal effects in integrated circuits using CONCISE a waveform relaxation based circuit simulator. WR is a method that is suitable to run on a multi-computer with state of the art computing power. Especially CMOS VLSI circuits have been simulated successfully with WR. LÄS MER