Sökning: "PMN"

Visar resultat 21 - 25 av 43 avhandlingar innehållade ordet PMN.

  1. 21. War and peace in the tumor microenvironment : tumor-associated cells as facilitators or adversaries during tumor development

    Författare :Margarita Bartish; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The tumor microenvironment, including immune cells, fibroblasts and vasculature, profoundly affects tumor development by initially opposing, but eventually facilitating tumor growth, vascularization and spread. Though corrupted by the growing tumor, such cells remain non-transformed and thus, with proper cues, are possible to direct toward their physiological anti-tumor function. LÄS MER

  3. 22. Platelet function in polycythemia vera : studies of agonist and cytokine induced platelet activation

    Författare :Katarina Le Blanc; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Polycythemia vera (PV) is a malignant myeloproliferative disorder characterized by an increased red cell mass and most often accompanied by leukocytosis and thrombocytosis. The pathogenic mechanisms behind PV are still largely unknown. LÄS MER

  4. 23. Diagnostic and prognostic markers in sepsis

    Författare :Patrik Gille-Johnson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Sepsis is a life-threatening disease affecting millions of people globally. The more severe forms are considered to be a consequence of an unbalanced systemic inflammatory response to infection, causing organ dysfunction, vascular leakage and hypotension. An early diagnosis followed by appropriate antimicrobial therapy is critical for the outcome. LÄS MER

  5. 24. Role of the Yersinia protein YopK in microbe-host interactions

    Författare :Sara Thorslund; Maria Fällman; James Bliska; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Yersinia; YopK; T3SS; antiphagocytosis; neutrophil; translocation; virulence; molekylärbiologi; Molecular Biology;

    Sammanfattning : There are three human pathogenic species of the genus Yersiniae: Yersinia pestis, Yersinia enterocolitica, and Yersinia pseudotuberculosis. To cause disease, these strains inhibit several key innate defense mechanisms, including phagocytosis, the critical process for bacterial clearance. LÄS MER

  7. 25. C-reactive protein in clinical practice with special regard to infectious diseases

    Författare :Lars-Olof Hansson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :CRP; general practice; septi-caemia; endocarditis; influenza; bacterialmeningitis; viral meningitis; community-acquired pneumonia; malignant melanoma; albumin; transferrin; a-1 anti-trypsin; hapto-globin; orosomucoid; transthyretin; iron.;

    Sammanfattning : A new simple affinity purification method for human CRP using Arginine-Sepharose 4B was developed with a recovery of >90 % and containing < 5-10 % contaminating proteins. In a multicenter study including 607 consecutive patients in general practice, erythrocyte sedimentation rate (ESR) and serum CRP were compared. LÄS MER