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Visar resultat 6 - 10 av 184 avhandlingar som matchar ovanstående sökkriterier.

  1. 6. Hypoxia, PDGF and VEGF in Vascular Development

    Författare :Ingrid Nilsson; Lena Claesson-Welsh; Randall Johnson; Uppsala universitet; []
    Nyckelord :Cell biology; hypoxia; VEGF; VEGFR-3; PDGF; endothelial cell; embryonic stem cell; angiogenesis; lymphangiogenesis; Cellbiologi;

    Sammanfattning : The mechanisms behind many important aspects of blood- and lymphatic vessel formation have yet not been elucidated in detail. The primary objectives of this thesis have therefore been to study the effects of hypoxia, platelet-derived growth factor (PDGF) and vascular endothelial growth factors (VEGFs) on vascular development and function. LÄS MER

  3. 7. Inhibition of PDGF receptor signaling in tumor stroma : Effects on interstitial hypertension, drug uptake and therapeutic response

    Författare :Kristian Pietras; Sven Påhlman; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; PDGF; tumor; stroma; tyrosine kinase inhibitor; combination therapy; Onkologi; Oncology; Onkologi; molekylär cellbiologi; Molecular Cellbiology;

    Sammanfattning : The role of platelet-derived growth factor (PDGF) in malignancies involves both autocrine and paracrine stimulation of cells within the tumor. The interstitial fluid pressure (IFP) is one of the forces that govern the transvascular flow of fluids. LÄS MER

  4. 8. Effects of PDGF-B gene inactivation in endothelial cell

    Författare :Mattias Bjarnegård; Göteborgs universitet; []
    Nyckelord :gene targeting; Cre loxP; PDGF; pericyte; mouse; microangiopathy;

    Sammanfattning : Platelet-derived growth factor-B (PDGF-B) is expressed by endothelial cells, neurons, macrophages and platelets. The relative importance of these cellular PDGF-B sources in vivo has been addressed by the creation of a conditional PDGF-B allele, which in the presence of a specific recombinase can be silenced in different tissues. LÄS MER

  5. 9. A functional genomics approach to PDGF and pericyte biology

    Författare :Cecilia Bondjers; Göteborgs universitet; []
    Nyckelord :PDGF; hair follicle; skin; testis; epithelial-mesenchymal interaction; microarray; pericyte; transgenic mouse;

    Sammanfattning : The rapid expansion of genome sequence data demands for increased efforts and speed concerning functional analysis of gene products. Two approaches to such analysis, namely transgenic technologies and analysis of gene expression have successfully been used to study functions of gene products in complex organisms, such as mammals. LÄS MER

  7. 10. Roles of p16INk a and PDGF-B in glioma

    Författare :Lene Uhrbom; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; autocrine; glioma; INK4a; PDGF; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

    Sammanfattning : Gliomas are diffuse astrocytic tumors of the central nervous system (CNS) which usually affect adults. This thesis work has focused on molecular mechanisms of altered growth control in glioma, and the significance of two gene products belonging to pathways commonly affected in glioma, p16INK4a and PDGF-B, has been investigated in vitro and in vivo. LÄS MER