Sökning: "Neuronal cell culture"

Visar resultat 11 - 15 av 87 avhandlingar innehållade orden Neuronal cell culture.

  1. 11. Prion processing and propagation in neuronal and dendritic cell culture models

    Författare :Katarina M Luhr; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Prion; scrapie; cathepsin; processing; IFN-gamma; DRG; dendritic cell; cytokine;

    Sammanfattning : Prion diseases are rare neurodegenerative diseases, associated with a conversion of a normal cellular protein, PrPC, into its misfolded and partial protease resistant isoform, PrPSc. These diseases affect both animals and humans and are unique since they can not only be genetic and sporadic, but also transmissible. LÄS MER

  3. 12. Estimation of acute toxicity by using the differentiated neuronal progenitor C17.2 cell model

    Författare :Jessica Lundqvist; Anna Forsby; Ann-Kristin Östlund Farrants; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Neurotoxicity; C17.2; cell membrane potential; Optimisation culture condition; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Sammanfattning : The authorities in Europe and United States request information regarding possible toxicity for substances that are produced in one tonne or more per year. Estimation of acute systemic toxicity is conducted in vivo using mice or rats. LÄS MER

  4. 13. Human iPSC-derived neuronal networks. Development and application for compound evaluation

    Författare :Julia Izsak; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; human induced pluripotent stem cell; neuronal network; microelectrode array; in vitro;

    Sammanfattning : Research on human brain development and function in health and disease has been hampered by limited access to primary human tissue and limited translatability of animal studies. This knowledge gap is encouraging the use of human induced pluripotent stem cell (hiPSC)-derived neural in vitro models. LÄS MER

  5. 14. Mechanisms and improvements of cell transplantation for nerve repair

    Författare :Kai-Hei Tse; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mesenchymal stem cells; microporous scaffold; biomaterials; ischemia; cell death; brain derived neurotrophic factor;

    Sammanfattning : Trauma to the nervous system is a frequent clinical problem and new approaches to nerve repair are required. Autologous cell transplantation together with a suitable scaffold material could be used to create a bio-active artificial nerve graft to enhance regeneration. LÄS MER

  7. 15. Neuroblastoma SH-SY5Y and neural progenitor C17.2 cell lines as models for neurotoxicological studies​

    Författare :Jessica Lundqvist; Anna Forsby; Åsa Fex Svenningsen; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; SH-SY5Y; C17.2; in vitro neurotoxicity; cell culture conditions; biomarkers; in vitro developmental neurotoxicity; whole genome microarray; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Sammanfattning : We are surrounded by chemicals, thus understanding how exposure to these chemicals affect us during our life is of great social importance. In order to predict human acute toxicity of chemicals, cosmetics or drugs, development of novel in vitro test strategies is required. LÄS MER