Sökning: "N-terminal"

Visar resultat 26 - 30 av 513 avhandlingar innehållade ordet N-terminal.

  1. 26. Dual Targeting of Proteins to Mitochondria and Chloroplasts

    Författare :Anna-Karin Berglund; Elzbieta Glaser; Ophry Pines; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Biokemi; Biochemistry; biokemi;

    Sammanfattning : The vast majority of mitochondrial and chloroplastic proteins are nuclear encoded, synthesized in the cytosol and imported into the respective organelle using an N-terminal extension, the targeting peptide (TP). After import into the organelle, the TP is cleaved off and degraded by the Presequence protease (PreP). LÄS MER

  3. 27. Structural and biophysical studies of pneumococcal capsular surface proteins

    Författare :Cecilia Mikaelsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Streptococcus pneumoniae (pneumococcus) is a major human pathogen and a leading cause of morbidity and mortality worldwide, especially in children and the elderly. The casualties due to respiratory infections are estimated to be over 4 million per year, where pneumococcus is the predominant species. LÄS MER

  4. 28. Calcium signaling : molecular mechanisms and cellular consequences

    Författare :Seth Malmersjö; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cells exploit calcium (Ca2+) signaling to transmit information. In a multicellular organism, each cell must be able recognize, process, and respond to information received from the surrounding environment. In this thesis I investigate molecular mechanisms and cellular consequences of Ca2+ signaling. LÄS MER

  5. 29. Design and Synthesis of AT2 Receptor Selective Angiotensin II Analogues Encompassing β- and γ-Turn Mimetics

    Författare :Ulrika Rosenström; Anders Hallberg; Stephen Hanessian; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; Angiotensin II; AT2; AT1; Benzodiazepine; Peptidomimetics; γ-turn; β-turn; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi;

    Sammanfattning : Important information on the bioactive conformation of biologically active peptides may be obtained by studies of rigid peptides or well-defined secondary structure mimetics incorporated into pseudopeptides. The structural requirements for the interaction of angiotensin II (Ang II, Asp-Arg-Val-Tyr-Ile-His-Pro-Phe) with its AT1 and AT2 receptors were the subject of this study. LÄS MER

  7. 30. Galectin-8 specificity to cells: from broad outside to fine inside

    Författare :Susanne Nordenfelt; immunologi och glykobiologi - MIG Avdelningen för mikrobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biomedical sciences; Biomedicinska vetenskaper; Intracellular targeting; Sialic acid; Galectin fine specificity;

    Sammanfattning : Glycobiology is the world of sugars: how they are made, what they look like, and what they do. Despite the importance of glycan structures in life, knowledge has been hampered due to their inherent complexity. LÄS MER