Sökning: "Lipid Domains"
Visar resultat 11 - 15 av 73 avhandlingar innehållade orden Lipid Domains.
11. Prion-infection and Cellular Signaling : Influence of scrapie-infection on lipid raft-associated proteins
Sammanfattning : Prion diseases are a group of fatal neurodegenerative diseases affecting almost all mammals including humans. The diseases are caused by formation of the misfolded isoform of the cellular prion protein (PrPC) to the disease causing PrPSc. LÄS MER
12. Plasma membrane order; the role of cholesterol and links to actin filaments
Sammanfattning : The connection between T cell activation, plasma membrane order and actin filament dynamics was the main focus of this study. Laurdan and di-4-ANEPPDHQ, membrane order sensing probes, were shown to report only on lipid packing rather than being influenced by the presence of membrane-inserted peptides justifying their use in membrane order studies. LÄS MER
13. Responding Model Membranes. Lipid Phase Behaviour, Domain Formation and Permeability
Sammanfattning : This thesis concerns the interplay between the lipid phase behaviour, domain formation and the permeability of bilayer membranes. An essential part of this work has been the understanding of the phase transitions and equilibrium properties of lipid bilayers. LÄS MER
14. Roles of PI3-kinase and ARAP2 in regulating glucose metabolism
Sammanfattning : Insulin signaling is mediated by a complex, highly integrated network which functions to control multiple metabolic and growth processes throughout the organism. A key enzyme in the insulin signaling network is phosphatidylinositol 3-kinase (PI3-kinase). LÄS MER
15. Cholesterol in T cells : homeostasis, plasma membrane organization and signaling
Sammanfattning : The plasma membrane of eukaryotic cells contains cholesterol and glycosphingolipids enriched nanodomains known as lipid rafts; which are believed to exist in a liquid ordered (lo) state. Methyl-beta-cyclodextrin (MBCD) is used to deplete cellular cholesterol and a widespread assumption is that MBCD preferentially targets cholesterol in lipid rafts. LÄS MER