Sökning: "allogeneic DCs"
Visar resultat 1 - 5 av 17 avhandlingar innehållade orden allogeneic DCs.
1. Allogeneic dendritic cells as adjuvants in cancer immunotherapy
Sammanfattning : In recent years, immunotherapeutic approaches have achieved remarkable successes through checkpoint blockade antibodies, advances in the use of chimeric antigen receptor (CAR) T cells and new insights into the immunosuppressive role of the tumor microenvironment (TME). Through the advances, the role of cancer vaccines based on ex vivo manipulated autologous dendritic cells (DC) has been challenged. LÄS MER
2. Cellular immune responses in allogeneic and xenogeneic transplantation models
Sammanfattning : The introduction of immunosuppressive agents and improvements in surgical techniques and ancillary care has made allotransplantation a routine procedure. However, improvements in short-term graft survival rates have not been accompanied by a similar improvement in long-term outcome due to the process of therapy-resistant chronic allograft rejection. LÄS MER
3. Improvement of adoptive T-cell therapy for Cancer
Sammanfattning : Cancer immunotherapy has recently made remarkable clinical progress. Adoptive transfer of T-cells engineered with a chimeric antigen receptor (CAR) against CD19 has been successful in treatment of B-cell leukemia. LÄS MER
4. Studies on dendritic cells in multiple sclerosis and experimental allergic encephalomyelitis
Sammanfattning : Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) resulting in demyelination, axonal loss and, ultimately, formation of gliotic scar tissue in the brain and spinal cord. MS remains the major disabling neurological illness of young adults of North European origin. LÄS MER
5. Dendritic cell responses to apoptotic cells : is there life after death?
Sammanfattning : Dendritic cells (DC) are antigen-presenting cells that are crucial for the induction of immune responses to pathogens and for the maintenance of self-tolerance. DCs efficiently capture and process material from their local environment, including invading pathogens and dying cells of the host, and present the material to the adaptive immune response. LÄS MER