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Visar resultat 1 - 5 av 7 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Studies of Retroviral Reverse Transcriptase and Flaviviral Protease Enzymes as Antiviral Drug Targets : Applications in Antiviral Drug Discovery & Therapy

   Författare :Muhammad Junaid; Jarl ES Wikberg; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Virus; enzymes; HIV AIDS; retroviral reverse transcriptase; flaviviral protease; NRTIs; proteochemometrics; drug resistance; DEN; JEV; NS2B H -NS3pro; antiviral; drug targets; drug discovery; drug therapy.; Farmakologi; Pharmacology;

   Sammanfattning : Viruses are a major threat to humans due to their unique adaptability, evolvability and  capability to control their hosts as parasites and genetic elements. HIV/AIDS is the third largest cause of death by infectious diseases in the world, and drug resistance due to the viral mutations is still the leading cause of treatment failure. LÄS MER

3. 2. Japanese encephalitis virus in pigs and vectors in the Mekong Delta : with special reference to urban farming

   Författare :Johanna Lindahl; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
   Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES;

   Sammanfattning : Japanese encephalitis Virus (JEV) is a mosquito-borne flavivirus in East and South Asia, estimated to cause 60 000 human cases of Japanese encephalitis each year. The main transmission cycle for JEV is via mosquito vectors, mainly Culex species, between pigs and wading birds, the reservoir hosts. LÄS MER

4. 3. B cell responses to human flavivirus vaccination and SARS-CoV-2 infection

   Författare :Tyler Sandberg; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Viral infections pose a major threat to global heath. As specific antiviral treatments are lacking against many human viruses, vaccination is the most effective medical intervention to prevent severe disease and death. Delineating the immune events following viral vaccination and infection can help in the design of new vaccines and therapeutics. LÄS MER

5. 4. Interplay between tick-borne encephalitis virus and the host innate immunity

   Författare :Chaitanya Kurhade; Anna Överby Wernstedt; Nelson Gekara; Helen Lazear; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Virology; Flavivirus; IPS-1; Interferon; Viperin; mikrobiologi; Microbiology;

   Sammanfattning : Flaviviruses are important emerging and re-emerging arthropod-borne pathogens that cause significant morbidity and mortality in humans. It consists of globally distributed human pathogens such as tick-borne encephalitis virus (TBEV), West Nile virus (WNV), Japanese encephalitis virus (JEV), yellow fever virus (YFV), dengue virus (DENV), and Zika virus (ZIKV). LÄS MER

7. 5. The influence of urban livestock-keeping on the epidemiology of mosquito-borne zoonotic flaviviruses in Hanoi city of Vietnam

   Författare :Long Pham-Thanh; Johanna Lindahl; Åke Lundkvist; Ulf Magnusson; Flavie Goutard; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; urban livestock-keeping; mosquito borne zoonotic flaviviruses; knowledge and practices; vector abundance; risk factors; Hanoi; Vietnam;

   Sammanfattning : In rapid urbanizing cities, the high density of livestock populations in close vicinity to humans, and high mosquito vector abundance have provided suitable conditions for transmission of mosquito-borne zoonotic flaviviruses, that cause several million cases of human disease annually. This thesis explores the urban livestock-keeping in Hanoi and its potential influence on the epidemiology of flavivirus infections. LÄS MER