Sökning: "Jöns Hilborn"

Visar resultat 16 - 20 av 20 avhandlingar innehållade orden Jöns Hilborn.

  1. 16. Regulating Gene Expression to Promote Osteoblastic Differentiation of Stem Cells

    Författare :Maruthibabu Paidikondala; Oommen P. Varghese; Jöns Hilborn; Laura Creemers; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Kemi med inriktning mot polymerkemi; Chemistry with specialization in Polymer Chemistry;

    Sammanfattning : Bone is a tissue that heals by itself, unless the defect is too large (critical size). Today, novel regenerative medicine approaches have emerged as an alternative to treat such defects. This thesis explores alternative therapeutic strategies for bone tissue engineering which are biocompatible and clinically translatable. LÄS MER

  3. 17. Biomaterials for Promoting Self-Healing of Bone Tissue

    Författare :Sonya Piskounova; Jöns Hilborn; Tim Bowden; Simon Cool; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Osseointegration; implant coating; hyaluronan hydrogel; bone morphogenetic protein-2; hydroxyapatite; bone; delivery system; injectable; mixing; radioactive labeling; Kemi med inriktning mot polymerkemi; Chemistry with specialization in Polymer Chemistry;

    Sammanfattning : The present work addresses poor bone/implant integration and severe bone defects. In both conditions external stimuli is required for new bone to form. LÄS MER

  4. 18. Injectable Composite Hydrogels Based on Metal-Ligand Assembly for Biomedical Applications

    Författare :Liyang Shi; Jöns Hilborn; Dmitri Ossipov; Wenxin Wang; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; injectable; hydrogel; shear-thinning; self-healing; coordination chemistry; biomedical applications;

    Sammanfattning : This thesis presents new strategies to construct injectable hydrogels and their various biomedical applications, such as 3D printing, regenerative medicine and drug delivery. These hydrogels cross-linked by dynamic metal-ligand coordination bonds exhibit shear-thinning and self-healing properties, resulting in the unlimited time window for injection. LÄS MER

  5. 19. Heparan Sulfate Proteoglycans in Brain Tumor Development

    Författare :Argyris Spyrou; Karin Forsberg Nilsson; Fredrik Johansson Swartling; Jöns Hilborn; John Couchman; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glioma; pediatric brain tumors; heparanase; NDST1; heparan sulfate proteoglycans; CD24; glycosaminoglycan mimetics; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi;

    Sammanfattning : Malignant brain tumors are aggressive neoplasms that remain challenging to treat in spite of their detailed molecular characterization. Both adults and children may suffer from brain tumors, which, if not lethal, can cause severe long-term and devastating side effects. LÄS MER

  7. 20. Mechanical and swelling properties of hydrogels

    Författare :Ting Yang; Anders Hult; Michael Malkoch; Jöns Hilborn; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY;

    Sammanfattning : Hydrogels have been used as one of the novel soft materials in many biomedical applications such as drug delivery and tissue engineering for recent decades.In the main part of this work, bi-functional poly(ethylene glycol) (PEG) precursors with either thiols (PEG-SH) or allyls (PEG-Al) , covering molecular weights from 3 kDa to 8 kDa were synthesized and thoroughly characterized by 1H NMR, 13C NMR, FT-Raman and MALDI-TOF techniques. LÄS MER