Sökning: "hyaluronan hydrogel"

Visar resultat 1 - 5 av 13 avhandlingar innehållade orden hyaluronan hydrogel.

  1. 1. Hyaluronan Derivatives and Injectable Gels for Tissue Engineering

    Författare :Kristoffer Bergman; Tim Bowden; Jöns Hilborn; Jeffrey Hubbell; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Hyaluronan; Hydrogel; Tissue Engineering; Scaffold; Minimally invasive strategy; Bone morphogenetic protein; Hydroxyapatite; Bone; Cartilage; Tendon; Polymer chemistry; Polymerkemi;

    Sammanfattning : The present work describes the preparation of hyaluronan derivatives and hydrogels with potential use in tissue engineering applications. A potentially injectable hydrogel consisting of hyaluronan and collagen was successfully used to grow neurons in vitro by encapsulation of neural stem and progenitor cells. LÄS MER

  3. 2. Hyaluronan Based Biomaterials with Imaging Capacity for Tissue Engineering

    Författare :Yu Zhang; Dmitri Ossipov; Carsten Werner; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; hyaluronan; hydrogel; scaffold; tissue engineering; imaging; interpenetrating network; MRI; fluorescence imaging; scaffold degradation;

    Sammanfattning : This thesis presents the preparation of hyaluronan-based biomaterials with imaging capability and their application as scaffolds in tissue engineering. First, we have synthesized HA derivatives functionalized with different chemoselective groups. LÄS MER

  4. 3. Relating the Bulk and Interface Structure of Hyaluronan to Physical Properties of Future Biomaterials

    Författare :Ida Berts; Jöns Hilborn; Adrian R Rennie; Giovanna Fragneto; John W White; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; hyaluronan; structure; bulk; interface; small-angle neutron scattering; neutron reflection; hydrogel; grafting; nanoparticles; protein interactions;

    Sammanfattning : This dissertation describes a structural investigation of hyaluronan (HA) with neutron scattering techniques. HA is a natural biopolymer and one of the major components of the extracellular matrix, synovial fluid, and vitreous humor. LÄS MER

  5. 4. Multi-functional Hyaluronan Based Biomaterials for Biomedical Applications

    Författare :Xia Yang; Dmitri Ossipov; Matthias Lutolf; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; hyaluronan; biomaterials functionalizations; biomedical applications; orthogonal chemistry; drug delivery; tissue regeneration; MRI; Kemi med inriktning mot polymerkemi; Chemistry with specialization in Polymer Chemistry;

    Sammanfattning : This thesis presents strategies for constructing multi-functional biomaterials based on hyaluronan (HA) derivatives for various biomedical applications, such as drug delivery, tissue regeneration, and imaging biomaterials. The aim of this study is to improve the functionalities of HA biomaterials as well as simplify the preparation procedures. LÄS MER

  7. 5. Modular Hyaluronan-Based Hydrogels for 3D Cell Culture and Bioprinting

    Författare :Michael Jury; Daniel Aili; Robert Selegård; My Hedhammar; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Hyaluronan; 3D cell-culture; Biofunctionality; Bioprinting;

    Sammanfattning : Three-dimensional (3D) cell culture facilitates development of biological relevant assays for drug screening and toxicity testing. Compared to conventional 2D cell culture, cells cultured in 3D can more accurately mimic human tissues and organs and thus provide ex vivo data with potentially better predictive value for cancer research, pharmacology, and toxicology, reducing the need for animal models, improving experimental reproducibility, and reducing time and costs in drug development. LÄS MER