Sökning: "Immunological profile"

Visar resultat 1 - 5 av 64 avhandlingar innehållade orden Immunological profile.

1. 1. Prediction of Spontaneous Preterm Birth : Clinical and Immunological Aspects

   Författare :Maria Svenvik; Jan Ernerudh; Marie Blomberg; Maria Jenmalm; Teresa Cobo; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : Background: Preterm birth (PTB), defined as birth before 37 weeks of gestation, accounts for most neonatal death and morbidity. Accurate prediction is a pre-requisite for the prevention and proper management of PTB. However, methods for prediction are unsatisfactory, although sonographic cervical length has a moderate predictive value. LÄS MER

3. 2. Immunological profile and aspects of immunotherapy in type 1 diabetes

   Författare :Maria Hjorth; Maria Faresjö; Johnny Ludvigsson; Rosaura Casas; Vivianne Malmström; Linköpings universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Immunology; Immunologi;

   Sammanfattning : Type 1 diabetes (T1D) is a chronic, autoimmune disease caused by a T cell mediated attack on the insulin producing pancreatic ß-cells. Even though reasonable quality of life can be acquired with modern insulin therapy, prevention of acute and late serious complications is facilitated by preservation of residual insulin secretion. LÄS MER

4. 3. Treatment with the monoclonal antibody rituximab in Multiple Sclerosis : a study based on an academic clinical trial

   Författare :Pierre de Flon; Anders Svenningsson; Martin Gunnarsson; Katarina Laurell; Sten Fredrikson; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Multiple sclerosis; Rituximab; Cytokines; Immunological profile; Neurofilament light; Treatment satisfaction; neurologi; Neurology;

   Sammanfattning : Background: Multiple sclerosis (MS) is a chronic, inflammatory disease, affecting the central nervous system. A growing number of disease modifying treatment alternatives entails a need for an individualised risk-benefit- convenience analysis in the counselling of patients and methods to monitor the treatment effect, including markers for subclinical inflammation. LÄS MER

5. 4. Neuroborreliosis in childhood : Clinical, immunological and diagnostic aspects

   Författare :Barbro Hedin Skogman; Pia Forsberg; Jan Ernerudh; Birger Trollfors; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neuroborreliosis; Immune response; Diagnostics; Children; Lyme Borreliosis; Paediatric medicine; Pediatrisk medicin;

   Sammanfattning : Lyme Borreliosisis is a multi-organ infectious disease caused by the spirochete Borrelia burgdorferi. The spirochete is transmitted to humans by tick bites. Neuroborreliosis (NB) is a disseminated form of the disease, in which the spirochetes invade the nervous system. LÄS MER

7. 5. Systemic sclerosis : vascular, pulmonary and immunological aspects

   Författare :Grethe Neumann Andersen; Solbritt Rantapää Dahlqvist; Lucia Mincheva-Nilsson; Sören Jacobsen; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Systemic sclerosis; interstitial lung disease; MMP-9; Th1 Th2; transcription factors; NO; iNOS; E-selectin; endothelium-dependent dilation; endothelium-independent dilation.; Rheumatology; Reumatologi;

   Sammanfattning : In systemic sclerosis (SSc), interstitial lung disease (ILD) and engagement of the vascular system lead to increased morbidity and mortality. The aim of this thesis was to elucidate, in a consecutively included cohort of SSc (limited and diffuse) patients (n = 33), the T cell cytokine profile driving the disease in ILD and to explore the role of matrix metalloproteinase 9 (MMP-9) and its inhibitor: tissue inhibitor of metalloproteinase 1 (TIMP-1) in the extracellular matrix (ECM) degrading process leading to fibrous scarring and honey combing. LÄS MER