Sökning: "endothelium-dependent dilation"

Hittade 4 avhandlingar innehållade orden endothelium-dependent dilation.

  1. 1. Systemic sclerosis : vascular, pulmonary and immunological aspects

    Författare :Grethe Neumann Andersen; Solbritt Rantapää Dahlqvist; Lucia Mincheva-Nilsson; Sören Jacobsen; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Systemic sclerosis; interstitial lung disease; MMP-9; Th1 Th2; transcription factors; NO; iNOS; E-selectin; endothelium-dependent dilation; endothelium-independent dilation.; Rheumatology; Reumatologi;

    Sammanfattning : In systemic sclerosis (SSc), interstitial lung disease (ILD) and engagement of the vascular system lead to increased morbidity and mortality. The aim of this thesis was to elucidate, in a consecutively included cohort of SSc (limited and diffuse) patients (n = 33), the T cell cytokine profile driving the disease in ILD and to explore the role of matrix metalloproteinase 9 (MMP-9) and its inhibitor: tissue inhibitor of metalloproteinase 1 (TIMP-1) in the extracellular matrix (ECM) degrading process leading to fibrous scarring and honey combing. LÄS MER

  3. 2. Cardiovascular dysfunction in obstructive sleep apnea

    Författare :Holger Kraiczi; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Obstructive sleep apnea; blood pressure; cardiac size; left ventricular function; endothelium-dependent vasodilation; forearm vascular conductance; natriuretic peptides;

    Sammanfattning : This thesis addresses relationships between the presence or severity of obstructive sleep apnea (OSA) and blood pressure (BP) as well as other signs of cardiovascular dysfunction.In a cross-sectional investigation of a sleep laboratory cohort of 81 patients, a dose response relationship was observed between the number of apneas plus hypopneas per hour of sleep (apnea-hypopnea index, AHI; measured with polysomnography) and office systolic and diastolic BP (SBP and DBP), daytime ambulatory DBP as well as nighttime ambulatory SBP and DBP (all ambulatory measurements taken at 20-minute intervals). LÄS MER

  4. 3. Studies on vasoactivity of fibrin(ogen) derived peptides

    Författare :Katarina Saldeen; Asrar Malik; Linköpings universitet; []
    Nyckelord :Fibrin ogen derived peptides; vasoactivity; prostacyclin; nitric oxide; angiotensin converting enzyme; MEDICINE; MEDICIN;

    Sammanfattning : Fibrin accumulation is a common fmding in many pathological conditions, such as in inflammatory processes, e.g. in the lungs in pneumonia or pulmonary insufficiency after sepsis. During lysis of the fibrin by plasmin or leukocyte elastase, peptides are released that may contribute to the pathophysiological changes. LÄS MER

  5. 4. The role of leptin in endothelial dysfunction and cardiovascular disease

    Författare :Manuel Cruz Gonzalez Garcia; Stefan Söderberg; Jan Engvall; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; leptin; obesity; endothelial dysfunction; cardiovascular disease; kardiologi; Cardiology;

    Sammanfattning : Objective:  Obesity has become the leading cause of mortality worldwide; however, the fundamental pathophysiology underlying this association remains unclear. The discovery of adipokines, i.e., cytokines produced by adipose cells (adipocytes), revealed that adipose tissue is a highly endocrine organ, thus opening new lines of investigation. LÄS MER